Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07RLW
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| Former ID |
DNC012780
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| Drug Name |
5-Aminomethyl-naphthalen-2-ol
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| Synonyms |
5-Aminomethyl-naphthalen-2-ol; 5-(aminomethyl)naphthalen-2-ol; CHEMBL131174; 170244-98-1; SCHEMBL15345565; CTK4D3537; DTXSID00658388; BDBM50061315; ZINC13766764; 1-(Aminomethyl)-6-hydroxynaphthalene; AKOS027292253; SC-29498; 1,2-Anthracenediol,10-(aminomethyl)-9,10-dihydro-
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C11H11NO
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| Canonical SMILES |
C1=CC2=C(C=CC(=C2)O)C(=C1)CN
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| InChI |
1S/C11H11NO/c12-7-9-3-1-2-8-6-10(13)4-5-11(8)9/h1-6,13H,7,12H2
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| InChIKey |
PFFJJFRURKJERG-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor alpha-2A (ADRA2A) | Target Info | Inhibitor | [1] |
| Adrenergic receptor alpha-2B (ADRA2B) | Target Info | Inhibitor | [1] | |
| Adrenergic receptor alpha-2C (ADRA2C) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | cGMP-PKG signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Panther Pathway | Alpha adrenergic receptor signaling pathway | |||
| Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Reactome | Adrenoceptors | |||
| Adrenaline signalling through Alpha-2 adrenergic receptor | ||||
| Adrenaline,noradrenaline inhibits insulin secretion | ||||
| G alpha (i) signalling events | ||||
| G alpha (z) signalling events | ||||
| Surfactant metabolism | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| Platelet Aggregation (Plug Formation) | ||||
| Integration of energy metabolism | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inh... J Med Chem. 1997 Dec 5;40(25):3997-4005. | |||
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