Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07SYG
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| Former ID |
DNC012495
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| Drug Name |
2,3-Dihydro-1H-isoindole
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| Synonyms |
Isoindoline; 496-12-8; 2,3-dihydro-1H-isoindole; 1H-Isoindole, 2,3-dihydro-; Isoindoline, 97%; CHEMBL118475; GWVMLCQWXVFZCN-UHFFFAOYSA-N; iso-indoline; 2-Azaindan; 1,3-dihydroisoindole; 1,2-dihydroisoindole; PubChem16248; ACMC-1AM9E; AC1Q1IE0; AC1L9MF9; 1,3-dihydro-2H-isoindole; SCHEMBL10612; KSC222C5F; SCHEMBL2764305; CTK1C2152; MolPort-000-165-448; KS-000013BD; BCP01139; ACN-S003606; ZINC4111883; ACN-S001460; ANW-30800; STK077165; BDBM50052887; AN-716; BBL000565; AKOS000283835; TRA0077123; RTC-060566; CM10320; MB01342
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C8H9N
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| Canonical SMILES |
C1C2=CC=CC=C2CN1
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| InChI |
1S/C8H9N/c1-2-4-8-6-9-5-7(8)3-1/h1-4,9H,5-6H2
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| InChIKey |
GWVMLCQWXVFZCN-UHFFFAOYSA-N
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| CAS Number |
CAS 496-12-8
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor alpha-2A (ADRA2A) | Target Info | Inhibitor | [1] |
| Adrenergic receptor alpha-2B (ADRA2B) | Target Info | Inhibitor | [1] | |
| Adrenergic receptor alpha-2C (ADRA2C) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | cGMP-PKG signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Panther Pathway | Alpha adrenergic receptor signaling pathway | |||
| Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Reactome | Adrenoceptors | |||
| Adrenaline signalling through Alpha-2 adrenergic receptor | ||||
| Adrenaline,noradrenaline inhibits insulin secretion | ||||
| G alpha (i) signalling events | ||||
| G alpha (z) signalling events | ||||
| Surfactant metabolism | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| Platelet Aggregation (Plug Formation) | ||||
| Integration of energy metabolism | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46. | |||
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