Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07UBG
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| Former ID |
DAP001412
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| Drug Name |
Olmesartan medoxomil
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| Synonyms |
Benevas; Benicar; Olmetec; Olvance; Forest Brand of Olmesartan Medoxomil; Olmesartan medoximil; Sankyo Brand of Olmesartan Medoxomil; Cs 866; Benicar (TN); Berlin-Chemie Brand of Olmesartan Medoxomil; CS-866; CS-866DM; CS-866RN; DE-092; KS-1182; Olmetec (TN); Benicar, Olmetec,Olmesartan; Olmesartan medoxomil (JAN/USAN); (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate; (5-methyl-2-oxo-1,3-dioxolen-4-yl)methoxy-4-(1-hydroxy-1-methylethyl)-2-propyl-1-(4-(2-(tetrazol-5-yl)phenyl)phenyl)methylimidazol-5-carboxylate; 1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-((2'-(1H-tetrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl)-, (5-methyl-2-oxo-1,3-dioxol-4-yl) methyl ester; 1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester; 1H-imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-,(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
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| Drug Type |
Small molecular drug
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| Indication | High blood pressure [ICD-11: BA00; ICD-10: I10; ICD-9: 401] | Approved | [1] | |
| Therapeutic Class |
Antihypertensive Agents
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| Structure |
 |
Download2D MOL |
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| Formula |
C29H30N6O6
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| Canonical SMILES |
CCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)C(=O)OCC5=C(OC(=O)O5)C)C(C)(C)O
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| InChI |
1S/C29H30N6O6/c1-5-8-23-30-25(29(3,4)38)24(27(36)39-16-22-17(2)40-28(37)41-22)35(23)15-18-11-13-19(14-12-18)20-9-6-7-10-21(20)26-31-33-34-32-26/h6-7,9-14,38H,5,8,15-16H2,1-4H3,(H,31,32,33,34)
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| InChIKey |
UQGKUQLKSCSZGY-UHFFFAOYSA-N
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| CAS Number |
CAS 144689-63-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7300489, 7848267, 10242742, 11364900, 11367462, 11370024, 11372810, 11374179, 11378194, 11484167, 11488322, 11491491, 11492555, 11495758, 11528908, 12014934, 14935211, 26612826, 26681017, 26748978, 26748979, 29309387, 48185250, 48334789, 53789233, 57343590, 78528258, 81040868, 81092830, 85209756, 85787984, 92124799, 92308046, 92308894, 92713789, 93302267, 93815139, 103770675, 104253234, 104373834, 124637431, 124757358, 124891848, 125164162, 125311925, 125341111, 126624592, 126655597, 126655871, 126669975
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| ChEBI ID |
CHEBI:31932
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| ADReCS Drug ID | BADD_D01603 | |||
| SuperDrug ATC ID |
C09CA08
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| SuperDrug CAS ID |
cas=144689634
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides caccae ATCC 43185
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Bacteroides caccae ATCC 43185 (log2FC = -2.254; p = 0.011). | |||
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Studied Microbe: Bacteroides cellulosilyticus DSM 14838
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Bacteroides cellulosilyticus DSM 14838 (log2FC = -1.932; p = 0.001). | |||
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Studied Microbe: Bacteroides coprophilus DSM 18228
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Bacteroides coprophilus DSM 18228 (log2FC = -1.003; p = 0.046). | |||
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Studied Microbe: Bacteroides dorei DSM 17855
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -3.057; p = 0.007). | |||
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Studied Microbe: Bacteroides finegoldii DSM17565
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Bacteroides finegoldii DSM17565 (log2FC = -1.139; p = 0.002). | |||
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Studied Microbe: Bacteroides fragilis ATCC43859
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -1.731; p = 0.009). | |||
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Studied Microbe: Bacteroides fragilis HMW 610
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -1.917; p = 0.007). | |||
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Studied Microbe: Bacteroides fragilis NCTC 9343
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -1.613; p = 0.047). | |||
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Studied Microbe: Bacteroides fragilis str. 3397 T10
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -1.344; p = 0.007). | |||
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Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -1.756; p = 0.011). | |||
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Studied Microbe: Bacteroides fragilis str. DS-208
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -1.657; p = 0.013). | |||
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Studied Microbe: Bacteroides intestinalis DSM 17393
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Bacteroides intestinalis DSM 17393 (log2FC = -1.818; p = 0.005). | |||
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Studied Microbe: Bacteroides stercoris ATCC 43183
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Bacteroides stercoris ATCC 43183 (log2FC = -1.105; p = 0.036). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -2.262; p = 0.01). | |||
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Studied Microbe: Bacteroides vulgatus ATCC 8482
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -3.366; p = 0.0). | |||
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Studied Microbe: Bacteroides xylanisolvens DSM18836
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -3.21; p = 0.003). | |||
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Studied Microbe: Odoribacter splanchnicus
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Odoribacter splanchnicus (log2FC = -1.674; p = 0.022). | |||
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Studied Microbe: Parabacteroides distasonis ATCC 8503
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -1.556; p = 0.011). | |||
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Studied Microbe: Parabacteroides johnsonii DSM 18315
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Parabacteroides johnsonii DSM 18315 (log2FC = -1.106; p = 0.032). | |||
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Studied Microbe: Pretovella copri DSM 18205
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Pretovella copri DSM 18205 (log2FC = -1.205; p = 0.005). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium breve DSM 20213
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Bifidobacterium breve DSM 20213 (log2FC = -1.016; p = 0.006). | |||
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Studied Microbe: Bifidobacterium longum subsp. Infantis CCUG52486
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Bifidobacterium longum subsp. Infantis CCUG52486 (log2FC = -0.442; p = 0.038). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
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Studied Microbe: Collinsella aerofaciens ATCC25986
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Collinsella aerofaciens ATCC25986 (log2FC = -1.244; p = 0.004). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eggerthellales | ||||
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Studied Microbe: Eggerthella lenta ATCC 25559
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Eggerthella lenta ATCC 25559 (log2FC = -0.92; p = 0.023). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
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Studied Microbe: Edwardsiella tarda ATCC 23685
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Edwardsiella tarda ATCC 23685 (log2FC = -0.522; p = 0.036). | |||
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Studied Microbe: Enterobacter cancerogenus ATCC35316
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Enterobacter cancerogenus ATCC35316 (log2FC = -0.923; p = 0.016). | |||
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Studied Microbe: Escherichia coli BW25113
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Escherichia coli BW25113 (log2FC = -0.717; p = 0.033). | |||
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Studied Microbe: Proteus penneri ATCC 35198
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Proteus penneri ATCC 35198 (log2FC = -0.556; p = 0.031). | |||
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Studied Microbe: Providencia stuartii ATCC 25827
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Providencia stuartii ATCC 25827 (log2FC = -0.75; p = 0.016). | |||
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Studied Microbe: Salmonella typhimurium LT2
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Salmonella typhimurium LT2 (log2FC = -1.166; p = 0.015). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Eubacterium biforme DSM 3989
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Eubacterium biforme DSM 3989 (log2FC = -1.253; p = 0.009). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Anaerostipes sp.
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Anaerostipes sp. (log2FC = -0.652; p = 0.046). | |||
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Studied Microbe: Anaerotruncus colihominis DSM 17241
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Anaerotruncus colihominis DSM 17241 (log2FC = -1.431; p = 0.0). | |||
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Studied Microbe: Bacteroides pectinophilus ATCC 43243
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Bacteroides pectinophilus ATCC 43243 (log2FC = -1.06; p = 0.019). | |||
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Studied Microbe: Bryantia formatexigens DSM 14469
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Bryantia formatexigens DSM 14469 (log2FC = -0.903; p = 0.004). | |||
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Studied Microbe: Clostridium asparagiforme DSM 15981
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Clostridium asparagiforme DSM 15981 (log2FC = -0.869; p = 0.023). | |||
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Studied Microbe: Clostridium difficile 120
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Clostridium difficile 120 (log2FC = -1.293; p = 0.011). | |||
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Studied Microbe: Clostridium hathewayi DSM 13479
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Clostridium hathewayi DSM 13479 (log2FC = -0.772; p = 0.01). | |||
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Studied Microbe: Clostridium symbiosum ATCC 14940
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Clostridium symbiosum ATCC 14940 (log2FC = -0.799; p = 0.023). | |||
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Studied Microbe: Dorea formicigenerans ATCC 27755
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Dorea formicigenerans ATCC 27755 (log2FC = -0.593; p = 0.005). | |||
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Studied Microbe: Enterocloster bolteae ATCC BAA-613
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Enterocloster bolteae ATCC BAA-613 (log2FC = -1.026; p = 0.014). | |||
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Studied Microbe: Eubacterium hallii DSM3353
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Eubacterium hallii DSM3353 (log2FC = -0.877; p = 0.012). | |||
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Studied Microbe: Eubacterium rectale ATCC 33656
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Eubacterium rectale ATCC 33656 (log2FC = -0.905; p = 0.02). | |||
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Studied Microbe: Eubacterium ventriosum ATCC 27560
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Eubacterium ventriosum ATCC 27560 (log2FC = -0.671; p = 0.004). | |||
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Studied Microbe: Ruminococcus lactaris ATCC 29176
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Ruminococcus lactaris ATCC 29176 (log2FC = -0.798; p = 0.049). | |||
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Studied Microbe: Subdoligranulum variabile DSM 15176
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Subdoligranulum variabile DSM 15176 (log2FC = -0.878; p = 0.038). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
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Studied Microbe: Lactobacillus reuteri CF48-3A
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Lactobacillus reuteri CF48-3A (log2FC = -0.515; p = 0.039). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Tissierellales | ||||
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Studied Microbe: Anaerococcus hydrogenalis DSM 7454
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Anaerococcus hydrogenalis DSM 7454 (log2FC = -0.939; p = 0.003). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Victivallales | ||||
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Studied Microbe: Victivallis vadensis ATCC BAA-548
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olmesartan medoxomil can be metabolized by Victivallis vadensis ATCC BAA-548 (log2FC = -0.968; p = 0.015). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Angiotensin II receptor type-1 (AGTR1) | Target Info | Antagonist | [3] |
| KEGG Pathway | Calcium signaling pathway | |||
| cGMP-PKG signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Adrenergic signaling in cardiomyocytes | ||||
| Vascular smooth muscle contraction | ||||
| Renin-angiotensin system | ||||
| Renin secretion | ||||
| Pathways in cancer | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| Panther Pathway | Angiotensin II-stimulated signaling through G proteins and beta-arrestin | |||
| Pathwhiz Pathway | Angiotensin Metabolism | |||
| Muscle/Heart Contraction | ||||
| Pathway Interaction Database | Arf6 trafficking events | |||
| Arf6 signaling events | ||||
| Angiopoietin receptor Tie2-mediated signaling | ||||
| Reactome | Peptide ligand-binding receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | ACE Inhibitor Pathway | |||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Peptide GPCRs | ||||
| Allograft Rejection | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Effect of angiotensin receptor blockade on endothelial function: focus on olmesartan medoxomil. Vasc Health Risk Manag. 2009;5(1):301-14. | |||
| REF 2 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 3 | Mechanism of diastolic stiffening of the failing myocardium and its prevention by angiotensin receptor and calcium channel blockers. J Cardiovasc Pharmacol. 2009 Jul;54(1):47-56. | |||
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