Drug Information
Drug General Information | Top | |||
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Drug ID |
D08FWK
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Former ID |
DIB005900
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Drug Name |
Oxypurinol
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Synonyms |
Oxypurinol (intravenous)
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Drug Type |
Small molecular drug
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Indication | Heart failure [ICD-11: BD10-BD13; ICD-10: I50, I50.9; ICD-9: 428] | Phase 2/3 | [1] | |
Company |
Johns Hopkins University
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Structure |
Download2D MOL |
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Formula |
C5H4N4O2
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Canonical SMILES |
C1=NNC2=C1C(=O)NC(=O)N2
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InChI |
1S/C5H4N4O2/c10-4-2-1-6-9-3(2)7-5(11)8-4/h1H,(H3,6,7,8,9,10,11)
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InChIKey |
HXNFUBHNUDHIGC-UHFFFAOYSA-N
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CAS Number |
CAS 2465-59-0
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PubChem Compound ID | ||||
ChEBI ID |
CHEBI:28315
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Target and Pathway | Top | |||
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Target(s) | Xanthine dehydrogenase/oxidase (XDH) | Target Info | Inhibitor | [2] |
BioCyc | Purine nucleotides degradation | |||
Urate biosynthesis/inosine 5'-phosphate degradation | ||||
Guanosine nucleotides degradation | ||||
Adenosine nucleotides degradation | ||||
Retinoate biosynthesis II | ||||
KEGG Pathway | Purine metabolism | |||
Caffeine metabolism | ||||
Drug metabolism - other enzymes | ||||
Metabolic pathways | ||||
Peroxisome | ||||
Panther Pathway | Adenine and hypoxanthine salvage pathway | |||
Purine metabolism | ||||
Pathwhiz Pathway | Caffeine Metabolism | |||
Purine Metabolism | ||||
Reactome | Purine catabolism | |||
WikiPathways | Oxidative Stress | |||
Effects of Nitric Oxide | ||||
Metabolism of nucleotides | ||||
Selenium Micronutrient Network |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT00063687) Oxypurinol Compared With Placebo for Class III-IV NYHA Congestive Heart Failure. U.S. National Institutes of Health. | |||
REF 2 | Oxypurinol as an inhibitor of xanthine oxidase-catalyzed production of superoxide radical. Biochem Pharmacol. 1988 Jan 15;37(2):349-52. |
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