Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08MYA
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| Drug Name |
PMID29649907-Compound-31
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| Drug Type |
Small molecular drug
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| Company |
SALK INSTITUTE FOR BIOLOGICAL STUDIE
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| Structure |
 |
Download2D MOL |
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| Formula |
C32H31F2N3O3
|
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| Canonical SMILES |
CN1C2=C(C=C(C=C2)C3=CC(=C(C=C3)CN(C4=CC(=CC(=C4)C=CC(=O)OC)F)C(=O)C5CCCCC5)F)C=N1
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| InChI |
1S/C32H31F2N3O3/c1-36-30-12-11-23(16-26(30)19-35-36)24-9-10-25(29(34)17-24)20-37(32(39)22-6-4-3-5-7-22)28-15-21(14-27(33)18-28)8-13-31(38)40-2/h8-19,22H,3-7,20H2,1-2H3/b13-8+/i20D
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| InChIKey |
FCAAOLBKZMXHIT-CPVMVVEOSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Farnesoid X-activated receptor (FXR) | Target Info | Agonist | [1] |
| Target's Patent Info | Farnesoid X-activated receptor (FXR) | Target's Patent Info | [1] | |
| KEGG Pathway | Bile secretion | |||
| Pathway Interaction Database | RXR and RAR heterodimerization with other nuclear receptor | |||
| Reactome | Recycling of bile acids and salts | |||
| PPARA activates gene expression | ||||
| Endogenous sterols | ||||
| WikiPathways | Nuclear Receptors in Lipid Metabolism and Toxicity | |||
| Nuclear Receptors Meta-Pathway | ||||
| Farnesoid X Receptor Pathway | ||||
| Drug Induction of Bile Acid Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. | |||
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