Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08RUX
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| Former ID |
DIB000506
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| Drug Name |
Z-321
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| Synonyms |
1-[3-(2-Indanylacetyl)thiazolidin-4(R)-ylcarbonyl]pyrrolidine; 1-[N-(2-Indanylacetyl)-4-thia-L-prolyl]pyrrolidine
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| Drug Type |
Small molecular drug
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| Indication | Parkinson disease [ICD-11: 8A00.0; ICD-9: 332] | Discontinued in Phase 1 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C19H24N2O2S
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| Canonical SMILES |
C1CCN(C1)C(=O)C2CSCN2C(=O)CC3CC4=CC=CC=C4C3
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| InChI |
1S/C19H24N2O2S/c22-18(11-14-9-15-5-1-2-6-16(15)10-14)21-13-24-12-17(21)19(23)20-7-3-4-8-20/h1-2,5-6,14,17H,3-4,7-13H2/t17-/m0/s1
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| InChIKey |
GDOVFSONSLOIAK-KRWDZBQOSA-N
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| CAS Number |
CAS 130849-58-0
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Prolyl endopeptidase (PREP) | Target Info | Modulator | [2] |
| KEGG Pathway | Renin-angiotensin system | |||
| Panther Pathway | Vasopressin synthesis | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003089) | |||
| REF 2 | Z-321, a prolyl endopeptidase inhibitor, augments the potentiation of synaptic transmission in rat hippocampal slices. Behav Brain Res. 1997 Feb;83(1-2):213-6. | |||
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