Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08TVU
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| Former ID |
DIB019556
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| Drug Name |
PMID20483621C5n
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| Synonyms |
GTPL8208; BDBM50321054
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C24H24ClF3N6
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| Canonical SMILES |
C1CN(CCN1)C2=NC=CC(=C2)C3=CC4=C(NCCN4CC5=C(C=CC(=C5)Cl)C(F)(F)F)N=C3
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| InChI |
1S/C24H24ClF3N6/c25-19-1-2-20(24(26,27)28)18(11-19)15-34-10-7-31-23-21(34)12-17(14-32-23)16-3-4-30-22(13-16)33-8-5-29-6-9-33/h1-4,11-14,29H,5-10,15H2,(H,31,32)
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| InChIKey |
AHZCYZMNFBGXAC-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | ALK tyrosine kinase receptor (ALK) | Target Info | Inhibitor | [1] |
| Doublecortin-like kinase 3 (DCLK3) | Target Info | Inhibitor | [2] | |
| MAPK/ERK kinase kinase 3 (MAP3K3) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Non-small cell lung cancer | |||
| NetPath Pathway | TSH Signaling Pathway | |||
| Panther Pathway | B cell activation | |||
| EGF receptor signaling pathway | ||||
| FGF signaling pathway | ||||
| Pathway Interaction Database | p38 MAPK signaling pathway | |||
| Regulation of p38-alpha and p38-beta | ||||
| IL1-mediated signaling events | ||||
| TNF receptor signaling pathway | ||||
| Reactome | Interleukin-1 signaling | |||
| WikiPathways | Differentiation Pathway | |||
| Insulin Signaling | ||||
| EGF/EGFR Signaling Pathway | ||||
| MAPK Cascade | ||||
| Structural Pathway of Interleukin 1 (IL-1) | ||||
| EBV LMP1 signaling | ||||
| TNF alpha Signaling Pathway | ||||
| IL-1 signaling pathway | ||||
| Interleukin-1 signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis and structure-activity relationships of 1,2,3,4-tetrahydropyrido[2,3-b]pyrazines as potent and selective inhibitors of the anaplastic lymphoma kinase. Bioorg Med Chem. 2010 Jun 15;18(12):4351-62. | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2007). | |||
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