Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08UPQ
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| Drug Name |
PMID25980951-Compound-30
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| Drug Type |
Small molecular drug
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| Company |
BRISTOL-MYERS SQUIBB COMPANY
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| Structure |
 |
Download2D MOL |
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| Formula |
C61H80FN9O7
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| Canonical SMILES |
CC(C1=CC=CC=C1F)N(CC2=CC=C(C=C2)C(=O)NC3CC(N(C3)C(=O)C(C(C)(C)C)NC(=O)C(C)NC)C(=O)NC4CCCC5=CC=CC=C45)C(=O)C6CC7=CC=CC=C7CN6C(=O)C(C(C)(C)C)NC(=O)C(C)NC
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| InChI |
1S/C61H80FN9O7/c1-36(63-10)53(72)67-51(60(4,5)6)58(77)70-34-43-21-13-12-20-42(43)31-50(70)57(76)69(38(3)45-23-16-17-25-47(45)62)33-39-27-29-41(30-28-39)55(74)65-44-32-49(56(75)66-48-26-18-22-40-19-14-15-24-46(40)48)71(35-44)59(78)52(61(7,8)9)68-54(73)37(2)64-11/h12-17,19-21,23-25,27-30,36-38,44,48-52,63-64H,18,22,26,31-35H2,1-11H3,(H,65,74)(H,66,75)(H,67,72)(H,68,73)/t36-,37-,38+,44-,48+,49-,50-,51+,52+/m0/s1
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| InChIKey |
SUVGZSPIXFUCLS-NQFXVQPCSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | X-linked inhibitor of apoptosis protein (XIAP) | Target Info | Antagonist | [1] |
| Target's Patent Info | X-linked inhibitor of apoptosis protein (XIAP) | Target's Patent Info | [1] | |
| KEGG Pathway | NF-kappa B signaling pathway | |||
| Ubiquitin mediated proteolysis | ||||
| Apoptosis | ||||
| Focal adhesion | ||||
| Toxoplasmosis | ||||
| HTLV-I infection | ||||
| Pathways in cancer | ||||
| Small cell lung cancer | ||||
| Panther Pathway | Apoptosis signaling pathway | |||
| Pathway Interaction Database | p75(NTR)-mediated signaling | |||
| BMP receptor signaling | ||||
| Caspase Cascade in Apoptosis | ||||
| TGF-beta receptor signaling | ||||
| Reactome | SMAC binds to IAPs | |||
| SMAC-mediated dissociation of IAP:caspase complexes | ||||
| Deactivation of the beta-catenin transactivating complex | ||||
| RIPK1-mediated regulated necrosis | ||||
| Regulation of TNFR1 signaling | ||||
| TNFR1-induced NFkappaB signaling pathway | ||||
| Regulation of necroptotic cell death | ||||
| WikiPathways | Copper homeostasis | |||
| Focal Adhesion | ||||
| Apoptosis | ||||
| Intrinsic Pathway for Apoptosis | ||||
| Apoptosis Modulation and Signaling | ||||
| NOD pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. | |||
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