Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08WBF
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| Former ID |
DCL000014
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| Drug Name |
BB-3644
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| Synonyms |
SCHEMBL609641
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Terminated | [1] | |
| Therapeutic Class |
Anticancer Agents
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| Company |
Vernalis
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| Structure |
 |
Download2D MOL |
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| Formula |
C20H32N4O5
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| Canonical SMILES |
CC(C)CC(C(C(=O)NO)OC)C(=O)NC(C(=O)NC1=CC=CC=N1)C(C)(C)C
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| InChI |
1S/C20H32N4O5/c1-12(2)11-13(15(29-6)18(26)24-28)17(25)23-16(20(3,4)5)19(27)22-14-9-7-8-10-21-14/h7-10,12-13,15-16,28H,11H2,1-6H3,(H,23,25)(H,24,26)(H,21,22,27)/t13-,15+,16-/m1/s1
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| InChIKey |
WORSVFBVUCBRIP-VNQPRFMTSA-N
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| CAS Number |
CAS 226072-63-5
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| PubChem Compound ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A phase I and pharmacological study of the matrix metalloproteinase inhibitor BB-3644 in patients with solid tumours. Br J Cancer. 2004 Feb 23;90(4):800-4. | |||
| REF 2 | Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy. Nat Rev Cancer. 2006 Mar;6(3):227-39. | |||
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