Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08WDW
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| Former ID |
DNC007826
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| Drug Name |
DYSIDENIN
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| Synonyms |
Isodysidenin; Dysidenine; Isodysidenine; (+)-Isodysidenin; 67528-34-1; 65647-65-6; AC1L2TGX; AC1Q5L6U; 5,5,5-trichloro-n2-methyl-n-[1-(1,3-thiazol-2-yl)ethyl]-n2-(4,4,4-trichloro-3-methylbutanoyl)leucinamide; A836069; 5,5,5-trichloro-4-methyl-2-[methyl-(4,4,4-trichloro-3-methylbutanoyl)amino]-N-[1-(1,3-thiazol-2-yl)ethyl]pentanamide; 5,5,5-trichloro-4-methyl-2-[methyl-(4,4,4-trichloro-3-methyl-1-oxobutyl)amino]-N-[1-(2-thiazolyl)ethyl]pentanamide; Pentanamide, 5,5,5-trichloro-4-methyl-2-(methyl(4,4,4-trichloro-3-methyl
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C17H23Cl6N3O2S
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| Canonical SMILES |
CC(CC(C(=O)NC(C)C1=NC=CS1)N(C)C(=O)CC(C)C(Cl)(Cl)Cl)C(Cl)(Cl)Cl
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| InChI |
1S/C17H23Cl6N3O2S/c1-9(16(18,19)20)7-12(14(28)25-11(3)15-24-5-6-29-15)26(4)13(27)8-10(2)17(21,22)23/h5-6,9-12H,7-8H2,1-4H3,(H,25,28)/t9-,10-,11-,12-/m0/s1
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| InChIKey |
BFVRAKVNXYQMID-BJDJZHNGSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Arachidonate 12-lipoxygenase (12-LOX) | Target Info | Inhibitor | [1] |
| Arachidonate 15-lipoxygenase (15-LOX) | Target Info | Inhibitor | [1] | |
| BioCyc | Resolvin D biosynthesis | |||
| Lipoxin biosynthesis | ||||
| KEGG Pathway | Arachidonic acid metabolism | |||
| Linoleic acid metabolism | ||||
| Metabolic pathways | ||||
| Serotonergic synapse | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| NetPath Pathway | IL4 Signaling Pathway | |||
| Panther Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | |||
| Pathwhiz Pathway | Arachidonic Acid Metabolism | |||
| Pathway Interaction Database | IL4-mediated signaling events | |||
| WikiPathways | Arachidonic acid metabolism | |||
| Eicosanoid Synthesis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg Med Chem. 2007 Nov 15;15(22):6900-8. | |||
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