Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09FWP
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| Former ID |
DNC005585
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| Drug Name |
6-(2-Hydroxy-phenyl)-naphthalen-2-ol
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| Synonyms |
CHEMBL195058; 6-(2-hydroxyphenyl)-2-naphthol; 6-(2-Hydroxy-phenyl)-naphthalen-2-ol; 2-methyl-6-o-tolylnaphthalene; SCHEMBL3016027; SMFVAKMYNVSVKJ-UHFFFAOYSA-N; BDBM50168378
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C16H12O2
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| Canonical SMILES |
C1=CC=C(C(=C1)C2=CC3=C(C=C2)C=C(C=C3)O)O
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| InChI |
1S/C16H12O2/c17-14-8-7-11-9-13(6-5-12(11)10-14)15-3-1-2-4-16(15)18/h1-10,17-18H
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| InChIKey |
SMFVAKMYNVSVKJ-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Estrogen receptor beta (ESR2) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Estrogen signaling pathway | |||
| Prolactin signaling pathway | ||||
| Pathway Interaction Database | Plasma membrane estrogen receptor signaling | |||
| Validated nuclear estrogen receptor beta network | ||||
| Validated nuclear estrogen receptor alpha network | ||||
| Reactome | Nuclear Receptor transcription pathway | |||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Ovarian Infertility Genes | ||||
| Integrated Pancreatic Cancer Pathway | ||||
| Nuclear Receptors | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. | |||
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