Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09LFY
|
|||
| Former ID |
DNC000786
|
|||
| Drug Name |
Il-8((3-73))K11R
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | C-X-C chemokine receptor type 1 (CXCR1) | Target Info | Agonist | [1] |
| C-X-C chemokine receptor type 2 (CXCR2) | Target Info | Agonist | [1] | |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Chemokine signaling pathway | ||||
| Endocytosis | ||||
| Epithelial cell signaling in Helicobacter pylori infection | ||||
| NetPath Pathway | TNFalpha Signaling Pathway | |||
| IL2 Signaling Pathway | ||||
| Panther Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | |||
| Interleukin signaling pathway | ||||
| Pathway Interaction Database | IL8- and CXCR2-mediated signaling events | |||
| IL8- and CXCR1-mediated signaling events | ||||
| Reactome | Chemokine receptors bind chemokines | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| Differentiation Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Il-8((3-73))K11R is a high affinity agonist of the neutrophil CXCR1 and CXCR2. Biochem Biophys Res Commun. 2001 Aug 24;286(3):595-600. | |||
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