Drug Information
Drug General Information | Top | |||
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Drug ID |
D09MAZ
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Former ID |
DIB021000
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Drug Name |
SX-517
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Synonyms |
SX-517; GTPL8501; SCHEMBL13197143; CHEMBL3342269; BDBM150811; US8981106, 1 (SX-517); N-(4-Fluorophenyl)-6-[2-(dihydroxyboryl)benzylthio]nicotinamide; [2-[[5-[(4-fluorophenyl)carbamoyl]pyridin-2-yl]sulfanylmethyl]phenyl]boronic acid
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C19H16BFN2O3S
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Canonical SMILES |
B(C1=CC=CC=C1CSC2=NC=C(C=C2)C(=O)NC3=CC=C(C=C3)F)(O)O
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InChI |
1S/C19H16BFN2O3S/c21-15-6-8-16(9-7-15)23-19(24)13-5-10-18(22-11-13)27-12-14-3-1-2-4-17(14)20(25)26/h1-11,25-26H,12H2,(H,23,24)
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InChIKey |
VZRIHFZJVIOJBE-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | C-X-C chemokine receptor type 2 (CXCR2) | Target Info | Antagonist | [1] |
KEGG Pathway | Cytokine-cytokine receptor interaction | |||
Chemokine signaling pathway | ||||
Endocytosis | ||||
Epithelial cell signaling in Helicobacter pylori infection | ||||
NetPath Pathway | TNFalpha Signaling Pathway | |||
Panther Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | |||
Interleukin signaling pathway | ||||
Pathway Interaction Database | IL8- and CXCR2-mediated signaling events | |||
Reactome | Chemokine receptors bind chemokines | |||
G alpha (i) signalling events | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Peptide GPCRs | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | Discovery of 2-[5-(4-Fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic Acid (SX-517): Noncompetitive Boronic Acid Antagonist of CXCR1 and CXCR2. J Med Chem. 2014 Oct 23;57(20):8378-97. |
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