Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D09PIN
|
|||
Former ID |
DNC001283
|
|||
Drug Name |
SB 224289
|
|||
Synonyms |
180083-23-2; (2'-Methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)(1'-methyl-6,7-dihydrospiro[furo[2,3-f]indole-3,4'-piperidin]-5(2H)-yl)methanone; SB224289; SB-224289; SB 224289; UNII-F95C648W4N; CHEMBL281350; CHEBI:64069; F95C648W4N; (4-(2-Methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)phenyl)-(1'-methylspiro(6,7-dihydro-2H-furo(2,3-f)indole-3,4'-piperidine)-5-yl)methanone
Click to Show/Hide
|
|||
Drug Type |
Small molecular drug
|
|||
Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
|||
Formula |
C32H32N4O3
|
|||
Canonical SMILES |
CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)N4CCC5=CC6=C(C=C54)C7(CCN(CC7)C)CO6
|
|||
InChI |
1S/C32H32N4O3/c1-20-16-25(30-33-21(2)39-34-30)8-9-26(20)22-4-6-23(7-5-22)31(37)36-13-10-24-17-29-27(18-28(24)36)32(19-38-29)11-14-35(3)15-12-32/h4-9,16-18H,10-15,19H2,1-3H3
|
|||
InChIKey |
ATQMRMGXINTJHV-UHFFFAOYSA-N
|
|||
CAS Number |
CAS 180083-23-2
|
|||
PubChem Compound ID | ||||
PubChem Substance ID |
4494824, 7980569, 9939000, 11111767, 11113970, 14909661, 24263016, 36152438, 47721701, 50104768, 53786940, 57356229, 80253748, 85209284, 103187893, 103984445, 111968726, 124750292, 124881379, 124881380, 126167850, 127457698, 134340737, 135610879, 135650993, 136367794, 137275801, 160830076, 163094386, 163394393, 163843200, 164023449, 179150087, 204434045, 206245871, 223535495, 225058079, 233326276, 250212574, 251965677, 252070144, 252089569, 252433862
|
|||
ChEBI ID |
CHEBI:64069
|
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | 5-HT 1B receptor (HTR1B) | Target Info | Antagonist | [2] |
KEGG Pathway | cAMP signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Serotonergic synapse | ||||
Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
5HT1 type receptor mediated signaling pathway | ||||
Reactome | Serotonin receptors | |||
G alpha (i) signalling events | ||||
WikiPathways | Serotonin HTR1 Group and FOS Pathway | |||
Monoamine GPCRs | ||||
GPCRs, Class A Rhodopsin-like | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
---|---|---|---|---|
REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 130). | |||
REF 2 | 5-hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5-HT1B receptor. Br J Pharmacol. 1999 Oct;128(3):730-4. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.