Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09SCI
|
|||
| Former ID |
DIB011195
|
|||
| Drug Name |
SKF-104351
|
|||
| Synonyms |
111908-94-2; Skf 104351; F 104351; 5H-Pyrrolo[1,2-a]imidazole,2-(4-fluorophenyl)-6,7-dihydro-3-(4-pyridinyl)-; 2-(4-fluorophenyl)-3-(4-pyridyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole; F-104351; AC1L3V0R; SCHEMBL7378515; DTXSID90149775; GJFVAEMLAFFGDZ-UHFFFAOYSA-N; ZINC3815711; 5H-Pyrrolo(1,2-a)imidazole, 2-(4-fluorophenyl)-6,7-dihydro-3-(4-pyridinyl)-; KB-292516; 2-p-Fluorophenyl-3-(4-pyridyl)-6,7-dihydro[5H]-pyrrolo[1,2-a]imidazole
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Rheumatoid arthritis [ICD-11: FA20] | Terminated | [1] | |
| Company |
SmithKline Beecham plc
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C17H14FN3
|
|||
| Canonical SMILES |
C1CC2=NC(=C(N2C1)C3=CC=NC=C3)C4=CC=C(C=C4)F
|
|||
| InChI |
1S/C17H14FN3/c18-14-5-3-12(4-6-14)16-17(13-7-9-19-10-8-13)21-11-1-2-15(21)20-16/h3-10H,1-2,11H2
|
|||
| InChIKey |
GJFVAEMLAFFGDZ-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 111908-94-2
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Arachidonate 5-lipoxygenase (5-LOX) | Target Info | Modulator | [2] |
| BioCyc | Aspirin-triggered lipoxin biosynthesis | |||
| Resolvin D biosynthesis | ||||
| Leukotriene biosynthesis | ||||
| Lipoxin biosynthesis | ||||
| Aspirin triggered resolvin D biosynthesis | ||||
| Aspirin triggered resolvin E biosynthesis | ||||
| KEGG Pathway | Arachidonic acid metabolism | |||
| Metabolic pathways | ||||
| Serotonergic synapse | ||||
| Ovarian steroidogenesis | ||||
| Toxoplasmosis | ||||
| NetPath Pathway | IL4 Signaling Pathway | |||
| Pathwhiz Pathway | Arachidonic Acid Metabolism | |||
| WikiPathways | Vitamin D Receptor Pathway | |||
| Arachidonic acid metabolism | ||||
| Eicosanoid Synthesis | ||||
| Selenium Micronutrient Network | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000933) | |||
| REF 2 | WO patent application no. 2006,1317,37, Method and composition for treating inflammatory disorders. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.