Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09VWI
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| Former ID |
DIB011115
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| Drug Name |
BRX-005
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| Synonyms |
Arimoclomol maleate; BRX-220; Bimoclomol derivatives, Biorex
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| Drug Type |
Small molecular drug
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| Indication | Diabetic foot ulcer [ICD-11: BD54; ICD-9: 707] | Phase 1 | [1] | |
| Amyotrophic lateral sclerosis [ICD-11: 8B60.0; ICD-9: 335.2] | Discontinued in Phase 2 | [2] | ||
| Company |
Biorex Research and Development Co
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| Structure |
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Download2D MOL |
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| Formula |
C14H20N4O
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| Canonical SMILES |
C1CCN(CC1)CC2CONC(=N2)C3=CN=CC=C3
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| InChI |
1S/C14H20N4O/c1-2-7-18(8-3-1)10-13-11-19-17-14(16-13)12-5-4-6-15-9-12/h4-6,9,13H,1-3,7-8,10-11H2,(H,16,17)
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| InChIKey |
QWVRTSZDKPRPDF-UHFFFAOYSA-N
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| CAS Number |
CAS 276690-58-5
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Heat shock protein 70 (HSP70) | Target Info | Modulator | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013054) | |||
| REF 2 | Bimoclomol: a nontoxic, hydroxylamine derivative with stress protein-inducing activity and cytoprotective effects. Nat Med. 1997 Oct;3(10):1150-4. | |||
| REF 3 | Cardiovascular effects of BRX-005 comparison to bimoclomol. Life Sci. 2000 Aug 25;67(14):1783-9. | |||
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