Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D09ZQN
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| Former ID |
DAP001015
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| Drug Name |
Dienestrol
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| Synonyms |
Agaldog; Cycladiene; Dehydrostilbestrol; Dehydrostilboestrol; Dienesterol; Dienestrolo; Dienestrolum; Dienoestrol; Dienol; Dinestrol; Dinovex; Estragard; Estraguard; Estrodienol; Estroral; Follidiene; Follormon; Gynefollin; Hormofemin; Isodienestrol; Oestrasid; Oestrodiene; Oestrodienol; Oestroral; Oestrovis; Restrol; Retalon; Sexadien; Synestrol; Teserene; Willnestrol; Dienestrolo [DCIT]; Dienoestrol [Nonsteroidal oestrogens]; Dienoestrol bp; Alpha-Dienestrol; DV (TN); Dienestrolum [INN-Latin]; Para-Dien; Restrol, Dienestrol; Dienestrol (E,E); Dienestrol (USP/INN); Dienestrol, (E,E)-Isomer; P,p'-(Diethylideneethylene)diphenol; Para,para'-(Diethylideneethylene)diphenol; Di(p-oxyphenyl)-2,4-hexadiene; Di(para-oxyphenyl)-2,4-hexadiene; Phenol, 4,4'-(1,2-diethylidene-1,2-ethanediyl)bis-, (E,E-(9CI); (E,E)-Dienestrol; 3,4-Bis(4-hydroxyphenyl)-2,4-hexadiene; 3,4-Bis(p-hydroxyphenyl)-2,4-hexadiene; 3,4-Bis(para-hydroxyphenyl)-2,4-hexadiene; 4,4'-(1,2-Diethylidene-1,2-ethanediyl)bisphenol; 4,4'-(2E,4E)-hexa-2,4-diene-3,4-diyldiphenol; 4,4'-(Diethylideneethylene)diphenol; 4,4'-Dihydroxy-gamma,delta-diphenyl-beta,delta-hexadiene; 4,4'-Hydroxy-gamma,delta-diphenyl-beta,delta-hexadiene; 4,4'-hexa-2,4-diene-3,4-diyldiphenol; 4-[(2E,4E)-4-(4-hydroxyphenyl)hexa-2,4-dien-3-yl]phenol
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| Drug Type |
Small molecular drug
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| Indication | Atrophic vaginitis [ICD-11: GA30.2; ICD-10: N95.2; ICD-9: 627.3] | Approved | [1], [2], [3] | |
| Therapeutic Class |
Estrogens
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| Structure |
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Download2D MOL |
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| Formula |
C18H18O2
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| Canonical SMILES |
CC=C(C1=CC=C(C=C1)O)C(=CC)C2=CC=C(C=C2)O
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| InChI |
1S/C18H18O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h3-12,19-20H,1-2H3/b17-3+,18-4+
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| InChIKey |
NFDFQCUYFHCNBW-SCGPFSFSSA-N
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| CAS Number |
CAS 13029-44-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
10290, 855694, 866306, 7847962, 8149299, 9276660, 10321153, 10536837, 15491054, 24869916, 24893737, 26611700, 26679878, 26746961, 26746962, 46504661, 47213198, 47365224, 47589030, 47736513, 48035154, 48035155, 48110473, 48110474, 48421888, 49698645, 50005377, 50123454, 50123455, 50950224, 53786970, 56352870, 56422141, 57408484, 57650731, 85148346, 85789335, 87567123, 89850272, 92124048, 92125902, 92307444, 92712307, 99301859, 103134881, 103272138, 103913634, 104253404, 109839953, 117617823
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| ChEBI ID |
CHEBI:4518
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| SuperDrug ATC ID |
G03CB01; G03CC02
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| SuperDrug CAS ID |
cas=000084173
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides caccae
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides caccae was decreased by Dienestrol (adjusted p-values: 1.22E-03). | |||
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Studied Microbe: Bacteroides fragilis enterotoxigenic
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides fragilis enterotoxigenic was decreased by Dienestrol (adjusted p-values: 5.99E-06). | |||
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Studied Microbe: Bacteroides fragilis nontoxigenic
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides fragilis nontoxigenic was decreased by Dienestrol (adjusted p-values: 2.62E-05). | |||
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Studied Microbe: Bacteroides ovatus
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides ovatus was decreased by Dienestrol (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Bacteroides thetaiotaomicron
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides thetaiotaomicron was decreased by Dienestrol (adjusted p-values: 2.83E-03). | |||
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Studied Microbe: Bacteroides uniformis
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides uniformis was decreased by Dienestrol (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Bacteroides vulgatus
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides vulgatus was decreased by Dienestrol (adjusted p-values: 7.01E-06). | |||
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Studied Microbe: Bacteroides xylanisolvens
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides xylanisolvens was decreased by Dienestrol (adjusted p-values: 4.93E-07). | |||
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Studied Microbe: Odoribacter splanchnicus
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Odoribacter splanchnicus was decreased by Dienestrol (adjusted p-values: 6.13E-06). | |||
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Studied Microbe: Parabacteroides distasonis
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides distasonis was decreased by Dienestrol (adjusted p-values: 5.51E-07). | |||
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Studied Microbe: Parabacteroides merdae
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides merdae was decreased by Dienestrol (adjusted p-values: 1.23E-05). | |||
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Studied Microbe: Prevotella copri
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Prevotella copri was decreased by Dienestrol (adjusted p-values: 1.88E-04). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia obeum
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Blautia obeum was decreased by Dienestrol (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Coprococcus comes
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Coprococcus comes was decreased by Dienestrol (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Dorea formicigenerans
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Dorea formicigenerans was decreased by Dienestrol (adjusted p-values: 8.43E-04). | |||
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Studied Microbe: Roseburia intestinalis
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia intestinalis was decreased by Dienestrol (adjusted p-values: 4.04E-03). | |||
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Studied Microbe: Ruminococcus gnavus
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus gnavus was decreased by Dienestrol (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Ruminococcus torques
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus torques was decreased by Dienestrol (adjusted p-values: 1.34E-05). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7160). | |||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 3 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 006110. | |||
| REF 4 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 5 | Potential use of an estrogen-glucocorticoid receptor chimera as a drug screen for tissue selective estrogenic activity. Bone. 2009 Jan;44(1):102-12. | |||
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