Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0A2FM
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| Former ID |
DNC003667
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| Drug Name |
6-(1H-Indole-2-sulfonyl)-2H-pyridazin-3-one
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| Synonyms |
indole, 20; CHEMBL72278; SCHEMBL4454291; BDBM16454; HXNAGYMCTAINEA-UHFFFAOYSA-N; Heterocyclic Sulfonylpyridazinone, 19a; 6-(indole-2-sulfonyl)-2H-pyridazin-3-one
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C12H9N3O3S
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| Canonical SMILES |
C1=CC=C2C(=C1)C=C(N2)S(=O)(=O)C3=NNC(=O)C=C3
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| InChI |
1S/C12H9N3O3S/c16-10-5-6-11(15-14-10)19(17,18)12-7-8-3-1-2-4-9(8)13-12/h1-7,13H,(H,14,16)
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| InChIKey |
HXNAGYMCTAINEA-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Aldose reductase (AKR1B1) | Target Info | Inhibitor | [1] |
| BioCyc | Methylglyoxal degradation III | |||
| Acetone degradation I (to methylglyoxal) | ||||
| KEGG Pathway | Pentose and glucuronate interconversions | |||
| Fructose and mannose metabolism | ||||
| Galactose metabolism | ||||
| Glycerolipid metabolism | ||||
| Metabolic pathways | ||||
| NetPath Pathway | IL1 Signaling Pathway | |||
| TGF_beta_Receptor Signaling Pathway | ||||
| Pathwhiz Pathway | Fructose and Mannose Degradation | |||
| Pyruvate Metabolism | ||||
| Pterine Biosynthesis | ||||
| Glycerolipid Metabolism | ||||
| Galactose Metabolism | ||||
| WikiPathways | Metapathway biotransformation | |||
| Polyol Pathway | ||||
| Metabolism of steroid hormones and vitamin D | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3... J Med Chem. 2005 Oct 6;48(20):6326-39. | |||
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