Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0A4EA
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| Former ID |
DNC010898
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| Drug Name |
OLEIC ACID
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| Synonyms |
oleic acid; 112-80-1; cis-9-Octadecenoic acid; cis-Oleic acid; Elaidoic acid; oleate; Glycon wo; Wecoline OO; Pamolyn 100; Glycon RO; (Z)-Octadec-9-enoic acid; Metaupon; Oelsauere; Vopcolene 27; Groco 5l; Groco 2; Groco 4; Groco 6; Tego-oleic 130; Emersol 211; Z-9-Octadecenoic acid; Industrene 206; Industrene 105; Pamolyn; Industrene 205; Oleinic acid; Emersol 213; Emersol 210; L'Acide oleique; cis-Octadec-9-enoic acid; Century cd fatty acid; Emersol 6321; Extraolein 90; Oleine 7503; 9-Octadecenoic acid (Z)-; Emersol 205; Emersol 233LL
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C18H34O2
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| Canonical SMILES |
CCCCCCCCC=CCCCCCCCC(=O)O
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| InChI |
1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/b10-9-
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| InChIKey |
ZQPPMHVWECSIRJ-KTKRTIGZSA-N
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| CAS Number |
CAS 112-80-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3978, 75221, 584561, 607054, 819801, 820852, 823248, 841649, 3140740, 4265936, 7849374, 7889573, 7889575, 8136926, 8144974, 10299740, 10504339, 11528277, 11532519, 14750979, 17388831, 24278605, 24856748, 24862437, 24886786, 24897936, 24897941, 24897944, 24897946, 24901337, 24901338, 26708080, 26732603, 26752911, 26759285, 29204451, 36888286, 46391972, 46392022, 46392136, 46393429, 48185141, 48417325, 48423867, 48425443, 49854224, 53789356, 56311729, 56314553, 56365484
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| ChEBI ID |
CHEBI:16196
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
| Studied Microbe: Gut microbiota unspecific | [2] | |||
| Microbial Enzyme | N-acylsynthase | |||
| Metabolic Reaction | Acylation | |||
| Description | Oleic acid can be metabolized by the N-acylsynthase of gut microbiota through acylation. | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Fatty acid-binding protein 1 (FABP1) | Target Info | Inhibitor | [3] |
| Fatty acid-binding protein 4 (FABP4) | Target Info | Inhibitor | [4] | |
| KEGG Pathway | PPAR signaling pathway | |||
| Fat digestion and absorption | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| Pathway Interaction Database | AP-1 transcription factor network | |||
| Reactome | Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis | |||
| Transcriptional regulation of white adipocyte differentiation | ||||
| PPARA activates gene expression | ||||
| Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||||
| WikiPathways | Lipid digestion, mobilization, and transport | |||
| Transcriptional Regulation of White Adipocyte Differentiation | ||||
| Nuclear Receptors Meta-Pathway | ||||
| PPAR Alpha Pathway | ||||
| Selenium Metabolism and Selenoproteins | ||||
| Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1054). | |||
| REF 2 | Gut Reactions: Breaking Down Xenobiotic-Microbiome Interactions. Pharmacol Rev. 2019 Apr;71(2):198-224. | |||
| REF 3 | Characterization of the drug binding specificity of rat liver fatty acid binding protein. J Med Chem. 2008 Jul 10;51(13):3755-64. | |||
| REF 4 | Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3675-9. | |||
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