Drug Information
Drug General Information | Top | |||
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Drug ID |
D0AN7B
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Former ID |
DAP000429
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Drug Name |
Melatonin
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Synonyms |
73-31-4; Melatonine; N-Acetyl-5-methoxytryptamine; Circadin; 5-Methoxy-N-acetyltryptamine; N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide; N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide; Melatol; Melovine; Melatonex; N-[2-(5-methoxyindol-3-yl)ethyl]acetamide; Acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-; UNII-JL5DK93RCL; N-(2-(5-Methoxyindol-3-yl)ethyl)acetamide; N-acetyl-5-methoxy-tryptamine; NSC 113928; CCRIS 3472; CHEMBL45; EINECS 200-797-7; JL5DK93RCL; Acetamide, N-(2-(5-methoxyindol-3-yl)ethyl)-; BRN 0205542; Circadin; Melapure; Melatonina; Posidorm; Vivitas; Night Rest; Pineal Hormone; Revital Melatonin; Rx Balance; Sleep Right; IN1244; M 5250; M1105; ML1; MT6; TNP00300; M-1200; M-1250; Mela-T; Melatonex, Melatonin; Melatonina (TN); NMR/14327425; Nature'S Harmony; PREVENTION 2 (MELATONIN); PREVENTION 3 (MELATONIN); PREVENTION 4 (MELATONIN); PREVENTION 5 (MELATONIN); PREVENTION 1 (MELATONIN) (PREVENTION 1); Acetamide, {N-[2-(5-methoxyindol-3-yl)ethyl]-}; Acetamide, N-[2-(5-methoxyindol-3-yl)ethyl]-(6CI,8CI); N-[2-(5-Methoxy-1H-indol-3-yl)-ethyl]-acetamide; Acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-(9CI); Acetamide, {N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-}; Acetamide, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)-(9CI); 4-ACETAMIDO-4'-ISOTHIO-CYANATOSTILBENE-2,2'-DISULFONIC ACID; [3H]melatonin; N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide
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Drug Type |
Small molecular drug
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Indication | Insomnia [ICD-11: 7A00-7A0Z] | Approved | [1], [2], [3] | |
Therapeutic Class |
Central Nervous System Stimulants
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Structure |
Download2D MOL |
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Formula |
C13H16N2O2
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Canonical SMILES |
CC(=O)NCCC1=CNC2=C1C=C(C=C2)OC
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InChI |
1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
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InChIKey |
DRLFMBDRBRZALE-UHFFFAOYSA-N
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CAS Number |
CAS 73-31-4
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PubChem Compound ID | ||||
PubChem Substance ID |
2961, 4752, 105815, 410775, 798411, 841969, 893664, 3133753, 4906256, 7636333, 7961516, 7979886, 8144655, 8149639, 8150851, 10321385, 10534170, 10589869, 11111467, 11111468, 11111469, 11221066, 11335528, 11360767, 11363079, 11365641, 11368203, 11372325, 11373730, 11376365, 11408768, 11461739, 11466486, 11467606, 11485263, 11486211, 11489160, 11491208, 11491881, 11493999, 11536797, 11537588, 14773848, 17388930, 17389536, 17405348, 24278103, 24439254, 26612030, 26679682
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ChEBI ID |
CHEBI:16796
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ADReCS Drug ID | BADD_D01373 | |||
SuperDrug ATC ID |
N05CH01
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SuperDrug CAS ID |
cas=000073314
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Interaction between the Drug and Microbe | Top | |||
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The Abundace of Studied Microbe(s) Regulated by Drug | ||||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Aeromonadales | ||||
Studied Microbe: Aeromonas
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[4] | |||
Hierarchy | ||||
Abundance Change | Increase | |||
Experimental Species | Sleep deprived mice | Experimental Sample | Frozen colon content | |
Disease or Condition | Intestinal barrier dysfunction | |||
Description | The abundance of Aeromonas was increased by Melatonin (p < 0.05). | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
Studied Microbe: Bacteroides
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[4] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experimental Species | Sleep deprived mice | Experimental Sample | Frozen colon content | |
Disease or Condition | Intestinal barrier dysfunction | |||
Description | The abundance of Bacteroides was decreased by Melatonin (p < 0.05). | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
Studied Microbe: Faecalibacterium
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[4] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experimental Species | Sleep deprived mice | Experimental Sample | Frozen colon content | |
Disease or Condition | Intestinal barrier dysfunction | |||
Description | The abundance of Faecalibacterium was decreased by Melatonin (p < 0.05). | |||
Studied Microbe: Lachnospiraceae
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[4] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experimental Species | Sleep deprived mice | Experimental Sample | Frozen colon content | |
Disease or Condition | Intestinal barrier dysfunction | |||
Description | The abundance of Lachnospiraceae was decreased by Melatonin (p < 0.05). | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
Studied Microbe: Streptococcaceae
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[4] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experimental Species | Sleep deprived mice | Experimental Sample | Frozen colon content | |
Disease or Condition | Intestinal barrier dysfunction | |||
Description | The abundance of Streptococcaceae was decreased by Melatonin (p < 0.05). | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Moraxellales | ||||
Studied Microbe: Moraxellaceae
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[4] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experimental Species | Sleep deprived mice | Experimental Sample | Frozen colon content | |
Disease or Condition | Intestinal barrier dysfunction | |||
Description | The abundance of Moraxellaceae was decreased by Melatonin (p < 0.05). | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Verrucomicrobiales | ||||
Studied Microbe: Akkermansia
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[4] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experimental Species | Sleep deprived mice | Experimental Sample | Frozen colon content | |
Disease or Condition | Intestinal barrier dysfunction | |||
Description | The abundance of Akkermansia was decreased by Melatonin (p < 0.05). | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
Studied Microbe: Bacteroidetes
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[4] | |||
Hierarchy | ||||
Abundance Change | Increase | |||
Experimental Species | Sleep deprived mice | Experimental Sample | Frozen colon content | |
Disease or Condition | Intestinal barrier dysfunction | |||
Description | The abundance of Bacteroidetes was increased by Melatonin (p < 0.05). | |||
Studied Microbe: Firmicutes
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[4] | |||
Hierarchy | ||||
Abundance Change | Increase | |||
Experimental Species | Sleep deprived mice | Experimental Sample | Frozen colon content | |
Disease or Condition | Intestinal barrier dysfunction | |||
Description | The abundance of Firmicutes was increased by Melatonin (p < 0.05). | |||
Studied Microbe: Gammaproteobacteria
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[4] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experimental Species | Sleep deprived mice | Experimental Sample | Frozen colon content | |
Disease or Condition | Intestinal barrier dysfunction | |||
Description | The abundance of Gammaproteobacteria was decreased by Melatonin (p < 0.05). |
Target and Pathway | Top | |||
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Target(s) | Melatonin receptor type 1A (MTNR1A) | Target Info | Binder | [5], [6], [7] |
Quinone reductase 2 (NQO2) | Target Info | Inhibitor | [8] | |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Circadian entrainment | ||||
Reactome | Class A/1 (Rhodopsin-like receptors) | |||
G alpha (i) signalling events | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Small Ligand GPCRs | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 224). | |||
REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
REF 3 | Melatonin and melatonergic drugs on sleep: possible mechanisms of action. Int J Neurosci. 2009;119(6):821-46. | |||
REF 4 | Role of melatonin in sleep deprivation-induced intestinal barrier dysfunction in mice. J Pineal Res. 2019 Aug;67(1):e12574. | |||
REF 5 | The human MT1 melatonin receptor stimulates cAMP production in the human neuroblastoma cell line SH-SY5Y cells via a calcium-calmodulin signal transduction pathway. J Neuroendocrinol. 2005 Mar;17(3):170-8. | |||
REF 6 | Coexpression of MT1 and RORalpha1 melatonin receptors in the Syrian hamster Harderian gland. J Pineal Res. 2005 Aug;39(1):21-6. | |||
REF 7 | Pharmacological characterization of human recombinant melatonin mt(1) and MT(2) receptors. Br J Pharmacol. 2000 Mar;129(5):877-86. | |||
REF 8 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. |
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