Drug Information
Drug General Information | Top | |||
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Drug ID |
D0B2BO
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Former ID |
DNC012491
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Drug Name |
6,7,8,9-Tetrahydro-5-thia-8-aza-benzocycloheptene
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Synonyms |
2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine; 58980-39-5; 2,3,4,5-tetrahydro-1,4-benzothiazepine; CHEMBL333343; 6,7,8,9-Tetrahydro-5-thia-8-aza-benzocycloheptene; 1,4-Benzothiazepine, 2,3,4,5-tetrahydro-; SCHEMBL2589907; CTK1D9777; DTXSID50483283; SUBDEKBXSIKCSA-UHFFFAOYSA-N; MolPort-022-153-088; BDBM50052886; 8761AB; ANW-63665; ZINC13757904; AKOS015856597; AJ-64367; AS-36127; KB-224927; TR-072578; AB0052636; ST24021452; FT-0733802; 2,3,4,5-tetrahydrobenzo[f]-1,4-thiazepine; X-3109; I14-16090
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C9H11NS
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Canonical SMILES |
C1CSC2=CC=CC=C2CN1
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InChI |
1S/C9H11NS/c1-2-4-9-8(3-1)7-10-5-6-11-9/h1-4,10H,5-7H2
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InChIKey |
SUBDEKBXSIKCSA-UHFFFAOYSA-N
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CAS Number |
CAS 58980-39-5
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Adrenergic receptor alpha-2A (ADRA2A) | Target Info | Inhibitor | [1] |
Adrenergic receptor alpha-2B (ADRA2B) | Target Info | Inhibitor | [1] | |
Adrenergic receptor alpha-2C (ADRA2C) | Target Info | Inhibitor | [1] | |
KEGG Pathway | cGMP-PKG signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Panther Pathway | Alpha adrenergic receptor signaling pathway | |||
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
Reactome | Adrenoceptors | |||
Adrenaline signalling through Alpha-2 adrenergic receptor | ||||
Adrenaline,noradrenaline inhibits insulin secretion | ||||
G alpha (i) signalling events | ||||
G alpha (z) signalling events | ||||
Surfactant metabolism | ||||
WikiPathways | Monoamine GPCRs | |||
GPCRs, Class A Rhodopsin-like | ||||
Platelet Aggregation (Plug Formation) | ||||
Integration of energy metabolism | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46. |
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