Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0B3BJ
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| Former ID |
DNC006842
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| Drug Name |
ICI-174864
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| Synonyms |
Ici-174864; Ici 174864; N,N-Diallyl-tyr-aib-phe-leu; N,N-Diallyl-tyrosyl-alpha-aminoisobutyric acid-phenylalanyl-leucine; L-Leucine, N-(N-(N-(N,N-di-2-propenyl-L-tyrosyl)-2-methylalanyl)-L-phenylalanyl)-; L-Leucine, N,N-di-2-propenyl-L-tyrosyl-2-methylalanyl-L-phenylalanyl-; AC1Q5QOV; AC1L32KD; SCHEMBL4402752; GTPL1636; PDSP2_001212; PDSP1_001228; n,n-di(prop-2-en-1-yl)-l-tyrosyl-2-methylalanyl-l-phenylalanyl-l-leucine; ICI-174,864; LS-178085
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C34H46N4O6
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| Canonical SMILES |
CC(C)CC(C(=O)O)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(C)(C)NC(=O)C(CC2=CC=C(C=C2)O)N(CC=C)CC=C
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| InChI |
1S/C34H46N4O6/c1-7-18-38(19-8-2)29(22-25-14-16-26(39)17-15-25)31(41)37-34(5,6)33(44)36-27(21-24-12-10-9-11-13-24)30(40)35-28(32(42)43)20-23(3)4/h7-17,23,27-29,39H,1-2,18-22H2,3-6H3,(H,35,40)(H,36,44)(H,37,41)(H,42,43)/t27-,28-,29-/m0/s1
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| InChIKey |
BGJPRBZZLWCLJW-AWCRTANDSA-N
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| CAS Number |
CAS 89352-67-0
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Opioid receptor delta (OPRD1) | Target Info | Inhibitor | [2] |
| KEGG Pathway | cGMP-PKG signaling pathway | |||
| Sphingolipid signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Enkephalin release | ||||
| Opioid proenkephalin pathway | ||||
| Opioid proopiomelanocortin pathway | ||||
| Reactome | Peptide ligand-binding receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1636). | |||
| REF 2 | Highly potent and selective phenylmorphan-based inverse agonists of the opioid delta receptor. J Med Chem. 2006 Sep 7;49(18):5597-609. | |||
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