Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0B7LK
|
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| Former ID |
DIB001914
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| Drug Name |
CY-1503
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| Synonyms |
Cylexin
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|
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| Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Phase 2/3 | [1] | |
| Company |
Epimmune Inc
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | E-selectin (SELE) | Target Info | Modulator | [2] |
| P-selectin (SELP) | Target Info | Modulator | [2] | |
| KEGG Pathway | Cell adhesion molecules (CAMs) | |||
| Malaria | ||||
| Staphylococcus aureus infection | ||||
| TNF signaling pathway | ||||
| African trypanosomiasis | ||||
| NetPath Pathway | IL5 Signaling Pathway | |||
| IL4 Signaling Pathway | ||||
| TNFalpha Signaling Pathway | ||||
| ID Signaling Pathway | ||||
| Pathway Interaction Database | IL4-mediated signaling events | |||
| amb2 Integrin signaling | ||||
| Thromboxane A2 receptor signaling | ||||
| Glucocorticoid receptor regulatory network | ||||
| ATF-2 transcription factor network | ||||
| Reactome | Platelet degranulation | |||
| Cell surface interactions at the vascular wall | ||||
| WikiPathways | Human Complement System | |||
| Spinal Cord Injury | ||||
| Cell surface interactions at the vascular wall | ||||
| TNF alpha Signaling Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00226369) Cylexin for Reduction of Reperfusion Injury in Infant Heart Surgery. U.S. National Institutes of Health. | |||
| REF 2 | Adjunctive selectin blockade successfully reduces infarct size beyond thrombolysis in the electrolytic canine coronary artery model. Circulation. 1995 Aug 1;92(3):492-9. | |||
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