Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D0B8SC
|
|||
Former ID |
DIB001878
|
|||
Drug Name |
BOF-4272
|
|||
Synonyms |
Rac-8-[3-Methoxy-4-(phenylsulfinyl)phenyl]pyrazolo[1,5-a]-1,3,5-triazin-4-ol sodium salt hydrate
Click to Show/Hide
|
|||
Drug Type |
Small molecular drug
|
|||
Indication | Gout [ICD-11: FA25; ICD-10: M10] | Discontinued in Phase 2 | [1] | |
Structure |
Download2D MOL
|
|||
Formula |
C18H13N4NaO3S
|
|||
Canonical SMILES |
COC1=C(C=CC(=C1)C2=C3[N-]C=NC(=O)N3N=C2)S(=O)C4=CC=CC=C4.[Na+]
|
|||
InChI |
1S/C18H14N4O3S.Na/c1-25-15-9-12(14-10-21-22-17(14)19-11-20-18(22)23)7-8-16(15)26(24)13-5-3-2-4-6-13;/h2-11H,1H3,(H,19,20,21,23);/q;+1/p-1
|
|||
InChIKey |
FRSOALVXQKHLLF-UHFFFAOYSA-M
|
|||
CAS Number |
CAS 142181-44-0
|
|||
PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Xanthine dehydrogenase/oxidase (XDH) | Target Info | Inhibitor | [2], [3] |
BioCyc | Purine nucleotides degradation | |||
Urate biosynthesis/inosine 5'-phosphate degradation | ||||
Guanosine nucleotides degradation | ||||
Adenosine nucleotides degradation | ||||
Retinoate biosynthesis II | ||||
KEGG Pathway | Purine metabolism | |||
Caffeine metabolism | ||||
Drug metabolism - other enzymes | ||||
Metabolic pathways | ||||
Peroxisome | ||||
Panther Pathway | Adenine and hypoxanthine salvage pathway | |||
Purine metabolism | ||||
Pathwhiz Pathway | Caffeine Metabolism | |||
Purine Metabolism | ||||
Reactome | Purine catabolism | |||
WikiPathways | Oxidative Stress | |||
Effects of Nitric Oxide | ||||
Metabolism of nucleotides | ||||
Selenium Micronutrient Network |
References | Top | |||
---|---|---|---|---|
REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002649) | |||
REF 2 | Enantioselective uptake of BOF-4272, a xanthine oxidase inhibitor with a chiral sulfoxide, by isolated rat hepatocytes. Yakugaku Zasshi. 2001 Dec;121(12):989-94. | |||
REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.