Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0C7WP
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| Former ID |
DNC007530
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| Drug Name |
SB-431542
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| Synonyms |
301836-41-9; SB-431542; SB 431542; 4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide; SB431542; UNII-E1557V1V0N; CHEMBL440084; E1557V1V0N; 4-[4-(1,3-BENZODIOXOL-5-YL)-5-(2-PYRIDINYL)-1H-IMIDAZOL-2-YL]BENZAMIDE; 4-(4-(1,3-Benzodioxole-5-yl)-5-(2-pyridyl)-1H-imidazole-2-yl)benzamide; SB 431542 hydrate; C22H16N4O3; 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide; 4-(4-Benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-benzamide
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| Drug Type |
Small molecular drug
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| Indication | Pulmonary fibrosis [ICD-11: CB03.4; ICD-10: J84.1] | Preclinical | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C22H16N4O3
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| Canonical SMILES |
C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
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| InChI |
1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)
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| InChIKey |
FHYUGAJXYORMHI-UHFFFAOYSA-N
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| CAS Number |
CAS 301836-41-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
6650475, 10210637, 11114151, 11121717, 11122197, 11362818, 11365380, 11367942, 11370867, 11370868, 11373543, 11376104, 14756106, 26752223, 29215044, 36836848, 47364893, 47868254, 48317022, 50100116, 50104911, 51661448, 53790221, 85788288, 87231679, 91746569, 92310068, 99300980, 99302500, 99436964, 103163932, 103905411, 104005054, 113096486, 121364788, 124349749, 124756974, 124887044, 125163779, 125333837, 126626059, 126660958, 126731475, 127849952, 134344735, 135685578, 135698494, 136144478, 136340199, 136345870
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| ChEBI ID |
CHEBI:91108
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs and Targets in Fibrosis. Front Pharmacol. 2017 Nov 23;8:855. | |||
| REF 2 | Pyrazolone based TGFbetaR1 kinase inhibitors. Bioorg Med Chem Lett. 2010 Jan 1;20(1):326-9. | |||
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