Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0CF2Q
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| Former ID |
DAP000570
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| Drug Name |
Levamisole
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| Synonyms |
Ketrax; LEVOMYSOL; Lepuron; Levamisol; Levamisolum; Levotetramisole; Tetramisol; Wormicid; Levamisole Base;Nilverm base; P00039; Vermisol 150; Dl-Tetramisol; Dl-Tetramisole; Ergamisol (TN); Ketrax (TN); L-Tetramisole; Levamisol [INN-Spanish]; Levamisole (INN); Levamisole [INN:BAN]; Levamisolum [INN-Latin]; TCMDC-125847; L(-)-Levamisole; L-2,3,5,6-Tetrahyro-6-phenylimidazo(2,1-b)thiazole; (-)-Tetramisole; (6S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole; (S)-(-)-Levamisole
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| Drug Type |
Small molecular drug
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| Indication | Parasitic infection [ICD-11: 1D0Y-1G2Z; ICD-10: B85-B89] | Approved | [1] | |
| Colon cancer [ICD-11: 2B90.Z] | Withdrawn from market | [2], [3] | ||
| Therapeutic Class |
Anticancer Agents
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| Company |
Janssen Pharmaceutica
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| Structure |
 |
Download2D MOL |
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| Formula |
C11H12N2S
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| Canonical SMILES |
C1CSC2=NC(CN21)C3=CC=CC=C3
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| InChI |
1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
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| InChIKey |
HLFSDGLLUJUHTE-SNVBAGLBSA-N
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| CAS Number |
CAS 14769-73-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9282, 602395, 7979761, 8169434, 10322011, 11335842, 11361081, 11364503, 11367065, 11369627, 11371883, 11374574, 11377789, 11405871, 11462053, 11466210, 11467330, 11484645, 11485760, 11488681, 11490777, 11492892, 11495423, 14748767, 15171780, 34669469, 46509052, 47440260, 47589003, 47736487, 47736488, 48035125, 48416165, 49761633, 49831041, 49981671, 50111118, 53790505, 56313649, 56313755, 57310333, 76000434, 85789251, 85860304, 90341409, 92309280, 92717075, 93166530, 96024804, 103523408
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| ChEBI ID |
CHEBI:6432
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| SuperDrug ATC ID |
P02CE01
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| SuperDrug CAS ID |
cas=014769734
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Alkaline phosphatase tissue-nonspecific (ALPL) | Target Info | Inhibitor | [4] |
| KEGG Pathway | Folate biosynthesis | |||
| Metabolic pathways | ||||
| NetPath Pathway | FSH Signaling Pathway | |||
| Pathwhiz Pathway | Vitamin B6 Metabolism | |||
| WikiPathways | Endochondral Ossification | |||
| BDNF signaling pathway | ||||
| AGE/RAGE pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7210). | |||
| REF 3 | New drugs in development for the treatment of endometriosis. Expert Opin Investig Drugs. 2008 Aug;17(8):1187-202. | |||
| REF 4 | Characterization of rat heart alkaline phosphatase isoenzymes and modulation of activity. Braz J Med Biol Res. 2008 Jul;41(7):600-9. | |||
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