Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0CS6N
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| Former ID |
DIB003439
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| Drug Name |
Benzodiazepine
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| Synonyms |
Benzodiazepine (Aversion, anxiety)
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| Drug Type |
Small molecular drug
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| Indication | Anxiety disorder [ICD-11: 6B00-6B0Z; ICD-10: R45.0] | Investigative | [1] | |
| Company |
Acura Pharmaceuticals Inc
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| Structure |
 |
Download2D MOL |
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| Formula |
C9H8N2
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| Canonical SMILES |
C1=CC=C2C(=C1)C=CC=NN2
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| InChI |
1S/C9H8N2/c1-2-6-9-8(4-1)5-3-7-10-11-9/h1-7,11H
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| InChIKey |
SVUOLADPCWQTTE-UHFFFAOYSA-N
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| CAS Number |
CAS 12794-10-4
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| PubChem Compound ID | ||||
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
| Studied Microbe: Gut microbiota unspecific | [2] | |||
| Microbial Enzyme | Nitroreductase | |||
| Metabolic Effect | Induce carcinogenicity | |||
| Description | Benzodiazepines can be metabolized by the nitroreductase of gut microbiota, which results in induction of the drug's carcinogenicity. | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Translocator protein (TSPO) | Target Info | Agonist | [1] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| HTLV-I infection | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2879). | |||
| REF 2 | Gut Reactions: Breaking Down Xenobiotic-Microbiome Interactions. Pharmacol Rev. 2019 Apr;71(2):198-224. | |||
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