Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0D1RU
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| Former ID |
DNC012021
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| Drug Name |
Indol-1-yl-pyridin-4-yl-amine
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| Synonyms |
119257-33-9; N-(4-pyridinyl)-1H-indol-1-amine; N-(PYRIDIN-4-YL)-1H-INDOL-1-AMINE; CHEMBL154488; 1H-Indol-1-amine,N-4-pyridinyl-; N-pyridin-4-ylindol-1-amine; N-4-Pyridinyl-1H-indol-1-amine; AC1MIWH0; ACMC-1C0H7; SCHEMBL3139425; ZINC24994; CTK4B1164; DTXSID90152360; YFXZWVUZIPQSKX-UHFFFAOYSA-N; BDBM50048608; 1H-Indol-1-amine, N-4-pyridinyl-; AKOS015924421; RP26505; KB-139314; J-523178
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C13H11N3
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| Canonical SMILES |
C1=CC=C2C(=C1)C=CN2NC3=CC=NC=C3
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| InChI |
1S/C13H11N3/c1-2-4-13-11(3-1)7-10-16(13)15-12-5-8-14-9-6-12/h1-10H,(H,14,15)
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| InChIKey |
YFXZWVUZIPQSKX-UHFFFAOYSA-N
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| CAS Number |
CAS 119257-33-9
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor alpha-2A (ADRA2A) | Target Info | Inhibitor | [1] |
| Adrenergic receptor alpha-2B (ADRA2B) | Target Info | Inhibitor | [1] | |
| Adrenergic receptor alpha-2C (ADRA2C) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | cGMP-PKG signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Panther Pathway | Alpha adrenergic receptor signaling pathway | |||
| Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Reactome | Adrenoceptors | |||
| Adrenaline signalling through Alpha-2 adrenergic receptor | ||||
| Adrenaline,noradrenaline inhibits insulin secretion | ||||
| G alpha (i) signalling events | ||||
| G alpha (z) signalling events | ||||
| Surfactant metabolism | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| Platelet Aggregation (Plug Formation) | ||||
| Integration of energy metabolism | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeu... J Med Chem. 1996 Jan 19;39(2):570-81. | |||
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