Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0D2WX
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| Former ID |
DNCL003573
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| Drug Name |
1614235 + 2330672
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| Synonyms |
AC1LUPX5
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| Drug Type |
Combination drug (small molecular drug)
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| Indication | Type-2 diabetes [ICD-11: 5A11; ICD-9: 250] | Phase 1 | [1] | |
| Company |
GlaxoSmithKline
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| Structure |
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| Formula |
C21H28NO3+
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| Canonical SMILES |
CC[NH+](CC)C(C)COC(=O)C(C1=CC=CC=C1)(C2=CC=CC=C2)O
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| InChI |
1S/C21H27NO3/c1-4-22(5-2)17(3)16-25-20(23)21(24,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6-15,17,24H,4-5,16H2,1-3H3/p+1/t17-/m1/s1
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| InChIKey |
DULUETYTNBOZNG-QGZVFWFLSA-O
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Ileal sodium/bile acid cotransporter (SLC10A2) | Target Info | Modulator | [2] |
| Sodium/glucose cotransporter 1 (SGLT1) | Target Info | Modulator | [3] | |
| KEGG Pathway | Carbohydrate digestion and absorption | |||
| Bile secretion | ||||
| Mineral absorption | ||||
| Pathwhiz Pathway | Lactose Degradation | |||
| Trehalose Degradation | ||||
| Reactome | Hexose transport | |||
| Na+-dependent glucose transporters | ||||
| Inositol transporters | ||||
| Recycling of bile acids and salts | ||||
| WikiPathways | NRF2 pathway | |||
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||||
| Metabolism of carbohydrates | ||||
| Bile acid and bile salt metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800037723) | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 960). | |||
| REF 3 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 915). | |||
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