Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0D3AS
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| Former ID |
DNC004681
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| Drug Name |
5-Nitro-2-(4-phenoxy-phenyl)-1H-benzoimidazole
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| Synonyms |
CHEMBL175481; 5-Nitro-2-(4-phenoxy-phenyl)-1H-benzoimidazole
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C19H13N3O3
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| Canonical SMILES |
C1=CC=C(C=C1)OC2=CC=C(C=C2)C3=NC4=C(N3)C=C(C=C4)[N+](=O)[O-]
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| InChI |
1S/C19H13N3O3/c23-22(24)14-8-11-17-18(12-14)21-19(20-17)13-6-9-16(10-7-13)25-15-4-2-1-3-5-15/h1-12H,(H,20,21)
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| InChIKey |
ZBWXPJPIZQAKGA-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Serine/threonine-protein kinase Chk2 (RAD53) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Cell cycle | |||
| p53 signaling pathway | ||||
| HTLV-I infection | ||||
| Pathway Interaction Database | ATM pathway | |||
| FOXM1 transcription factor network | ||||
| p53 pathway | ||||
| PLK3 signaling events | ||||
| Reactome | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | |||
| G2/M DNA damage checkpoint | ||||
| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | ||||
| WikiPathways | DNA Damage Response | |||
| ATM Signaling Pathway | ||||
| Integrated Pancreatic Cancer Pathway | ||||
| Prostate Cancer | ||||
| Integrated Breast Cancer Pathway | ||||
| Integrated Cancer pathway | ||||
| Cell Cycle | ||||
| miRNA Regulation of DNA Damage Response | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles. J Med Chem. 2005 Mar 24;48(6):1873-85. | |||
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