Drug Information
Drug General Information | Top | |||
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Drug ID |
D0D3OF
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Former ID |
DNC011825
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Drug Name |
1-(4-Bromo-2,5-dimethoxy-phenyl)-piperazine
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Synonyms |
CHEMBL348140; AC1NHEA9; 1-(2,5-dimethoxy-4-bromophenyl)piperazine; Oprea1_700068; BDBM50226218; AKOS003587698; 100939-87-5
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C12H17BrN2O2
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Canonical SMILES |
COC1=CC(=C(C=C1N2CCNCC2)OC)Br
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InChI |
1S/C12H17BrN2O2/c1-16-11-8-10(12(17-2)7-9(11)13)15-5-3-14-4-6-15/h7-8,14H,3-6H2,1-2H3
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InChIKey |
JLAQUWGWRNMYGA-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | 5-HT 1A receptor (HTR1A) | Target Info | Inhibitor | [1] |
5-HT 1D receptor (HTR1D) | Target Info | Inhibitor | [1] | |
5-HT 2A receptor (HTR2A) | Target Info | Inhibitor | [1] | |
KEGG Pathway | cAMP signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Serotonergic synapse | ||||
Calcium signaling pathway | ||||
Gap junction | ||||
Inflammatory mediator regulation of TRP channels | ||||
Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
5HT1 type receptor mediated signaling pathway | ||||
5HT2 type receptor mediated signaling pathway | ||||
Reactome | Serotonin receptors | |||
G alpha (i) signalling events | ||||
G alpha (q) signalling events | ||||
WikiPathways | Serotonin HTR1 Group and FOS Pathway | |||
Monoamine GPCRs | ||||
GPCRs, Class A Rhodopsin-like | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
SIDS Susceptibility Pathways | ||||
Serotonin Receptor 2 and STAT3 Signaling | ||||
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | ||||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents. J Med Chem. 1986 May;29(5):630-4. |
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