Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0D3PX
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| Former ID |
DCL001081
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| Drug Name |
SCH 727965
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| Synonyms |
Dinaciclib; SCH-727965
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| Drug Type |
Small molecular drug
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| Indication | Acute lymphoblastic leukaemia [ICD-11: 2A85; ICD-10: C85.1, C88.7] | Discontinued in Phase 3 | [1], [2], [3] | |
| Company |
Schering-Plough
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| Structure |
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Download2D MOL |
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| Formula |
C21H28N6O2
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| Canonical SMILES |
CCC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCCC4CCO
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| InChI |
1S/C21H28N6O2/c1-2-17-14-23-27-19(22-13-16-6-5-9-25(29)15-16)12-20(24-21(17)27)26-10-4-3-7-18(26)8-11-28/h5-6,9,12,14-15,18,22,28H,2-4,7-8,10-11,13H2,1H3/t18-/m0/s1
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| InChIKey |
PIMQWRZWLQKKBJ-SFHVURJKSA-N
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| CAS Number |
CAS 779353-01-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
99431612, 120930394, 124490344, 131407186, 134339476, 135264288, 136345849, 136367504, 136920416, 141002406, 152159564, 152258233, 160647069, 160692470, 162011589, 162205183, 172131336, 172918929, 174530706, 178103951, 185972567, 189622864, 198972887, 223387655, 223405957, 223681485, 223705097, 237165571, 242744373, 251910607, 251971097, 252110195, 252160440, 252215289, 252451690
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| ChEBI ID |
CHEBI:95060
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7379). | |||
| REF 2 | Dinaciclib, a novel CDK inhibitor, demonstrates encouraging single-agent activity in patients with relapsed multiple myeloma. Blood. 2015 Jan 15;125(3):443-8. | |||
| REF 3 | Cyclin-dependent kinase inhibitor Dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft models. Cancer Biol Ther. 2011 Oct 1;12(7):598-609. | |||
| REF 4 | Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. | |||
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