Drug Information
Drug General Information | Top | |||
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Drug ID |
D0D5DE
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Former ID |
DIB014787
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Drug Name |
ALPRENOXIME HYDROCHLORIDE
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Synonyms |
CDDD-1815; HGP-5; Alprenoxime hydrochloride; 1-(2-Allylphenoxy)-3-(isopropylamino)-2-propanone oxime monohydrochloride; 1-[(1-Methylethyl)amino]-3-[2-(2-propenyl)phenoxy]-2-propanone oxime monohydrochloride
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Drug Type |
Small molecular drug
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Indication | Glaucoma/ocular hypertension [ICD-11: 9C61; ICD-9: 365] | Discontinued in Phase 2 | [1] | |
Structure |
Download2D MOL |
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Formula |
C15H23ClN2O2
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Canonical SMILES |
CC(C)NCC(=NO)COC1=CC=CC=C1CC=C.Cl
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InChI |
1S/C15H22N2O2.ClH/c1-4-7-13-8-5-6-9-15(13)19-11-14(17-18)10-16-12(2)3;/h4-6,8-9,12,16,18H,1,7,10-11H2,2-3H3;1H
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InChIKey |
ZFLRDGZJSCQDSR-UHFFFAOYSA-N
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CAS Number |
CAS 121009-30-1
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Adrenergic receptor beta-3 (ADRB3) | Target Info | Modulator | [2] |
KEGG Pathway | Calcium signaling pathway | |||
cGMP-PKG signaling pathway | ||||
Neuroactive ligand-receptor interaction | ||||
Endocytosis | ||||
Salivary secretion | ||||
Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
Beta3 adrenergic receptor signaling pathway | ||||
Reactome | Adrenoceptors | |||
G alpha (s) signalling events | ||||
WikiPathways | Monoamine GPCRs | |||
Calcium Regulation in the Cardiac Cell | ||||
GPCRs, Class A Rhodopsin-like | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003470) | |||
REF 2 | Improved delivery through biological membranes. LVI. Pharmacological evaluation of alprenoxime--a new potential antiglaucoma agent. Pharm Res. 1991 Nov;8(11):1389-95. |
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