Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0DY5G
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| Former ID |
DIB020903
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| Drug Name |
SB 221284
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| Synonyms |
SB-221284; SB221284
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C16H14F3N3OS
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| Canonical SMILES |
CSC1=C(C=C2C(=C1)CCN2C(=O)NC3=CN=CC=C3)C(F)(F)F
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| InChI |
1S/C16H14F3N3OS/c1-24-14-7-10-4-6-22(13(10)8-12(14)16(17,18)19)15(23)21-11-3-2-5-20-9-11/h2-3,5,7-9H,4,6H2,1H3,(H,21,23)
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| InChIKey |
OQZOXHCRSXYSPM-UHFFFAOYSA-N
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| CAS Number |
CAS 196965-14-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
13906, 4910702, 10299303, 11114053, 14754355, 24724604, 29215039, 36886716, 51747596, 57404368, 85209599, 85787606, 91722300, 103176795, 103956181, 104629867, 128849265, 135650990, 135698234, 162022818, 162247322, 163123996, 164759717, 179294264, 184565830, 196393056, 202559424, 204360505, 206247055, 223440903, 223468627, 233943817, 241182378, 241375394, 252366105
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| ChEBI ID |
CHEBI:8978
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 2A receptor (HTR2A) | Target Info | Antagonist | [2] |
| 5-HT 2B receptor (HTR2B) | Target Info | Antagonist | [2] | |
| 5-HT 2C receptor (HTR2C) | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Gap junction | ||||
| Serotonergic synapse | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Panther Pathway | 5HT2 type receptor mediated signaling pathway | |||
| Reactome | Serotonin receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| Serotonin Receptor 2 and STAT3 Signaling | ||||
| SIDS Susceptibility Pathways | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 191). | |||
| REF 2 | Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23. | |||
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