Drug Information
Drug General Information | Top | |||
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Drug ID |
D0E0FY
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Former ID |
DIB013182
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Drug Name |
CTL-102-GDEPT
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Synonyms |
CTL-102; NTR-GDEPT; GDEPT (CTL-102), ML Laboratories; Gene directed chemotherapy (CTL-102), ML Laboratories; Ad-NTR + CB-1954 GDEPT, ML Labs; Human adenovirus (hAdV5) GDEPT (E coli nitroreductase (NTR)/CB-1954, aseptic prosthetic implant loosening), Broadvector
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Indication | Head and neck cancer [ICD-11: 2D42] | Discontinued in Phase 2 | [1] | |
Company |
Cobra Biomanufacturing plc
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Target and Pathway | Top | |||
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Target(s) | Aldose reductase (AKR1B1) | Target Info | Modulator | [2] |
BioCyc | Methylglyoxal degradation III | |||
Acetone degradation I (to methylglyoxal) | ||||
KEGG Pathway | Pentose and glucuronate interconversions | |||
Fructose and mannose metabolism | ||||
Galactose metabolism | ||||
Glycerolipid metabolism | ||||
Metabolic pathways | ||||
NetPath Pathway | IL1 Signaling Pathway | |||
TGF_beta_Receptor Signaling Pathway | ||||
Pathwhiz Pathway | Fructose and Mannose Degradation | |||
Pyruvate Metabolism | ||||
Pterine Biosynthesis | ||||
Glycerolipid Metabolism | ||||
Galactose Metabolism | ||||
WikiPathways | Metapathway biotransformation | |||
Polyol Pathway | ||||
Metabolism of steroid hormones and vitamin D |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011583) | |||
REF 2 | Genes in the Service of Therapeutic Index: Progress for Virus-Directed Enzyme Prodrug Therapy. JCO May 1, 2004 vol. 22 no. 9 1535-1537c. |
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