Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0E0MH
|
|||
| Drug Name |
PMID30259754-Compound-INT-767
|
|||
| Drug Type |
Small molecular drug
|
|||
| Company |
INTERCEPT PHARMACEUTICALS, INC. PELLICCIARI, Roberto FIORUCCI, Stefano PRUZANSKI, Mark
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C26H46O5S
|
|||
| Canonical SMILES |
CCC1C2CC(CCC2(C3CCC4(C(C3C1O)CCC4C(C)CCCS(=O)(=O)O)C)C)O
|
|||
| InChI |
1S/C26H46O5S/c1-5-18-22-15-17(27)10-12-26(22,4)21-11-13-25(3)19(8-9-20(25)23(21)24(18)28)16(2)7-6-14-32(29,30)31/h16-24,27-28H,5-15H2,1-4H3,(H,29,30,31)/t16-,17-,18-,19-,20+,21+,22+,23+,24-,25-,26-/m1/s1
|
|||
| InChIKey |
VJHHZJYLJUGVGO-JDCMAIOWSA-N
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Farnesoid X-activated receptor (FXR) | Target Info | Agonist | [1] |
| Target's Patent Info | Farnesoid X-activated receptor (FXR) | Target's Patent Info | [1] | |
| KEGG Pathway | Bile secretion | |||
| Pathway Interaction Database | RXR and RAR heterodimerization with other nuclear receptor | |||
| Reactome | Recycling of bile acids and salts | |||
| PPARA activates gene expression | ||||
| Endogenous sterols | ||||
| WikiPathways | Nuclear Receptors in Lipid Metabolism and Toxicity | |||
| Nuclear Receptors Meta-Pathway | ||||
| Farnesoid X Receptor Pathway | ||||
| Drug Induction of Bile Acid Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | FXR modulators for enterohepatic and metabolic diseases.Expert Opin Ther Pat. 2018 Nov;28(11):765-782. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.