Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0E3OL
|
|||
| Former ID |
DNC006910
|
|||
| Drug Name |
GNF-PF-2857
|
|||
| Synonyms |
GNF-PF-2857; CHEMBL217665; ChemDiv1_019259; N-(4-(4-methylpiperazin-1-yl)phenyl)quinolin-4-amine; N-[4-(4-methylpiperazin-1-yl)phenyl]quinolin-4-amine; AC1NCZHO; Oprea1_484208; SCHEMBL7129284; HMS641L09; ZINC1507915; BDBM50196110; AKOS024359777; MCULE-1778420008; ST50989409; [4-(4-methylpiperazinyl)phenyl]-4-quinolylamine; SR-01000394477; SR-01000394477-1
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C20H22N4
|
|||
| Canonical SMILES |
CN1CCN(CC1)C2=CC=C(C=C2)NC3=CC=NC4=CC=CC=C43
|
|||
| InChI |
1S/C20H22N4/c1-23-12-14-24(15-13-23)17-8-6-16(7-9-17)22-20-10-11-21-19-5-3-2-4-18(19)20/h2-11H,12-15H2,1H3,(H,21,22)
|
|||
| InChIKey |
RXXDJBWYJTWSKV-UHFFFAOYSA-N
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor alpha-2A (ADRA2A) | Target Info | Inhibitor | [1] |
| Adrenergic receptor alpha-2B (ADRA2B) | Target Info | Inhibitor | [1] | |
| Adrenergic receptor alpha-2C (ADRA2C) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | cGMP-PKG signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Panther Pathway | Alpha adrenergic receptor signaling pathway | |||
| Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Reactome | Adrenoceptors | |||
| Adrenaline signalling through Alpha-2 adrenergic receptor | ||||
| Adrenaline,noradrenaline inhibits insulin secretion | ||||
| G alpha (i) signalling events | ||||
| G alpha (z) signalling events | ||||
| Surfactant metabolism | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| Platelet Aggregation (Plug Formation) | ||||
| Integration of energy metabolism | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Structure-activity relationship of quinoline derivatives as potent and selective alpha(2C)-adrenoceptor antagonists. J Med Chem. 2006 Oct 19;49(21):6351-63. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.