Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0E3TC
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| Former ID |
DNC001380
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| Drug Name |
Staurosporine
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| Synonyms |
staurosporine; Staurosporin; (+)-Staurosporine; Antibiotic 230; 62996-74-1; Antibiotic AM 2282; CCRIS 3272; AM-2282; UNII-H88EPA0A3N; Alkaloid AM-2282 from Streptomyces; H88EPA0A3N; CHEMBL388978; CHEBI:15738; CGP 39360; 8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)trinden-1-one, 2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-10-(methylamino)-, (8alpha,9beta,10beta,12alpha)-(+)-
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C28H26N4O3
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| Canonical SMILES |
CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
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| InChI |
1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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| InChIKey |
HKSZLNNOFSGOKW-FYTWVXJKSA-N
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| CAS Number |
CAS 62996-74-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
597297, 831159, 841202, 3153154, 7890617, 7890621, 8032349, 11120145, 11120633, 11121121, 11147228, 11404389, 11538020, 14760668, 22395183, 22395940, 24844236, 26755744, 26755745, 34709538, 46392655, 46392942, 46393149, 46393168, 46393293, 46393541, 46393560, 46393654, 46394044, 46394184, 47439994, 47588763, 48258965, 49681204, 49965091, 50111287, 50751691, 53789987, 57312921, 57551949, 81060920, 81061213, 81064252, 85787454, 92310109, 92473422, 99437144, 100053925, 104225349, 117393230
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| ChEBI ID |
CHEBI:15738
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53. J Natl Cancer Inst. 1996 Jul 17;88(14):956-65. | |||
| REF 3 | Protein kinase C zeta isoform is critical for proliferation in human glioblastoma cell lines. J Neurooncol. 2000 Apr;47(2):109-15. | |||
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