Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0F2GG
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| Former ID |
DIB019853
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| Drug Name |
fenclonine
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| Synonyms |
4-chlorophenylalanine; para-chlorophenylalanine; PCPA
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C9H10ClNO2
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| Canonical SMILES |
C1=CC(=CC=C1CC(C(=O)O)N)Cl
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| InChI |
1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)
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| InChIKey |
NIGWMJHCCYYCSF-UHFFFAOYSA-N
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| CAS Number |
CAS 7424-00-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
118220, 3135847, 5350275, 7949976, 8149839, 8152858, 11336048, 11361287, 11364082, 11366644, 11369206, 11372830, 11374663, 11377368, 11462259, 11485173, 11489295, 11491581, 11492678, 11495002, 15463183, 17404849, 24278081, 26612319, 26679506, 26747140, 29223741, 47206090, 47515371, 47810805, 47959811, 48259290, 49865929, 49865930, 50104655, 50104656, 50104657, 51073443, 53777392, 53796052, 57322376, 79893731, 85084784, 85172960, 85172967, 85230975, 85788937, 87565413, 88837609, 89449664
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| ChEBI ID |
CHEBI:110187
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | L-Tryptophan hydroxylase 2 (TPH2) | Target Info | Inhibitor | [2] |
| Phenylalanine hydroxylase (PAH) | Target Info | Inhibitor | [3] | |
| Tryptophan 5-hydroxylase 1 (TPH1) | Target Info | Inhibitor | [4] | |
| BioCyc | Phenylalanine degradation/tyrosine biosynthesis | |||
| Superpathway of tryptophan utilization | ||||
| Serotonin and melatonin biosynthesis | ||||
| KEGG Pathway | Phenylalanine metabolism | |||
| Phenylalanine, tyrosine and tryptophan biosynthesis | ||||
| Metabolic pathways | ||||
| Biosynthesis of amino acids | ||||
| Tryptophan metabolism | ||||
| Serotonergic synapse | ||||
| Panther Pathway | 5-Hydroxytryptamine biosynthesis | |||
| Pathwhiz Pathway | Phenylalanine and Tyrosine Metabolism | |||
| Tryptophan Metabolism | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Biogenic Amine Synthesis | ||||
| Metabolism of amino acids and derivatives | ||||
| Abnormal metabolism in phenylketonuria | ||||
| Tryptophan metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5240). | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1242). | |||
| REF 3 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1240). | |||
| REF 4 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1241). | |||
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