Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0F7BV
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| Former ID |
DNC012635
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| Drug Name |
1-(1H-Indol-4-yloxy)-3-phenethylamino-propan-2-ol
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| Synonyms |
CHEMBL37989
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C19H22N2O2
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| Canonical SMILES |
C1=CC=C(C=C1)CCNCC(COC2=CC=CC3=C2C=CN3)O
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| InChI |
1S/C19H22N2O2/c22-16(13-20-11-9-15-5-2-1-3-6-15)14-23-19-8-4-7-18-17(19)10-12-21-18/h1-8,10,12,16,20-22H,9,11,13-14H2
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| InChIKey |
MDPRLCKPDFRPJV-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor beta-1 (ADRB1) | Target Info | Inhibitor | [1] |
| Adrenergic receptor beta-3 (ADRB3) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Calcium signaling pathway | |||
| cGMP-PKG signaling pathway | ||||
| cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Endocytosis | ||||
| Adrenergic signaling in cardiomyocytes | ||||
| Gap junction | ||||
| Salivary secretion | ||||
| Dilated cardiomyopathy | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Beta1 adrenergic receptor signaling pathway | ||||
| Beta3 adrenergic receptor signaling pathway | ||||
| Pathwhiz Pathway | Muscle/Heart Contraction | |||
| Reactome | Adrenoceptors | |||
| G alpha (s) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| Calcium Regulation in the Cardiac Cell | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Endothelin Pathways | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis and beta-adrenergic receptor blocking potency of 1-(substituted amino)-3-(4-indolyloxy)propan-2-ols. J Med Chem. 1986 Aug;29(8):1524-7. | |||
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