Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0F8TG
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| Former ID |
DIB019862
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| Drug Name |
fluperlapine
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| Synonyms |
C10967
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C19H20FN3
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| Canonical SMILES |
CN1CCN(CC1)C2=NC3=C(CC4=CC=CC=C42)C=CC(=C3)F
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| InChI |
1S/C19H20FN3/c1-22-8-10-23(11-9-22)19-17-5-3-2-4-14(17)12-15-6-7-16(20)13-18(15)21-19/h2-7,13H,8-12H2,1H3
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| InChIKey |
OBWGMKKHCLHVIE-UHFFFAOYSA-N
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| CAS Number |
CAS 67121-76-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
13150, 6609373, 7979279, 8181097, 12013044, 16827998, 26719743, 26754614, 29216069, 34714146, 46386904, 47212922, 47359854, 47657071, 48105148, 49681763, 50065048, 51161839, 57313198, 85209079, 85787799, 92308651, 92309148, 103259587, 103972301, 104357644, 118047217, 124659076, 124892258, 126418611, 128786630, 134222176, 135009043, 135650274, 137213959, 144205333, 162022405, 162221781, 163134726, 164824850, 170466413, 172080466, 176484515, 179150902, 184596034, 198943533, 223439752, 226509411, 241118261, 250081671
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| ChEBI ID |
CHEBI:5122
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 6 receptor (HTR6) | Target Info | Antagonist | [2] |
| 5-HT 7 receptor (HTR7) | Target Info | Antagonist | [2] | |
| KEGG Pathway | Ras signaling pathway | |||
| Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Serotonergic synapse | ||||
| cAMP signaling pathway | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Pathwhiz Pathway | Excitatory Neural Signalling Through 5-HTR 7 and Serotonin | |||
| Excitatory Neural Signalling Through 5-HTR 6 and Serotonin | ||||
| Reactome | Serotonin receptors | |||
| G alpha (s) signalling events | ||||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 279). | |||
| REF 2 | Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J Pharmacol Exp Ther. 1994 Mar;268(3):1403-10. | |||
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