Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0F8YO
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| Former ID |
DNC005401
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| Drug Name |
2-[3-(1-Hydroxy-propyl)-phenyl]-propionic acid
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| Synonyms |
SCHEMBL1345633; CHEMBL189037; Benzeneacetic acid, 3-(1-hydroxypropyl)-alpha-methyl-; AKOS023891992
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|
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C12H16O3
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| Canonical SMILES |
CCC(C1=CC=CC(=C1)C(C)C(=O)O)O
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| InChI |
1S/C12H16O3/c1-3-11(13)10-6-4-5-9(7-10)8(2)12(14)15/h4-8,11,13H,3H2,1-2H3,(H,14,15)
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| InChIKey |
HTWFANVWNDWYRH-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | C-X-C chemokine receptor type 1 (CXCR1) | Target Info | Inhibitor | [1] |
| C-X-C chemokine receptor type 2 (CXCR2) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Chemokine signaling pathway | ||||
| Endocytosis | ||||
| Epithelial cell signaling in Helicobacter pylori infection | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| TNFalpha Signaling Pathway | ||||
| Panther Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | |||
| Interleukin signaling pathway | ||||
| Pathway Interaction Database | IL8- and CXCR1-mediated signaling events | |||
| IL8- and CXCR2-mediated signaling events | ||||
| Reactome | Chemokine receptors bind chemokines | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Differentiation Pathway | ||||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. | |||
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