Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0FC0B
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| Drug Name |
PMID29649907-Compound-21
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| Drug Type |
Small molecular drug
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| Company |
ALIOS BIOPHARMA, INC
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| Structure |
 |
Download2D MOL |
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| Formula |
C29H22Cl3NO5
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| Canonical SMILES |
C1CC1C2=C(C(=NO2)C3=C(C=CC=C3Cl)Cl)COC4=CC5=C(C(=C4)Cl)OC(CC5)C6=CC(=CC=C6)C(=O)O
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| InChI |
1S/C29H22Cl3NO5/c30-21-5-2-6-22(31)25(21)26-20(27(38-33-26)15-7-8-15)14-36-19-12-17-9-10-24(37-28(17)23(32)13-19)16-3-1-4-18(11-16)29(34)35/h1-6,11-13,15,24H,7-10,14H2,(H,34,35)
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| InChIKey |
KCNYPNKMQPDXHA-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Farnesoid X-activated receptor (FXR) | Target Info | Agonist | [1] |
| Target's Patent Info | Farnesoid X-activated receptor (FXR) | Target's Patent Info | [1] | |
| KEGG Pathway | Bile secretion | |||
| Pathway Interaction Database | RXR and RAR heterodimerization with other nuclear receptor | |||
| Reactome | Recycling of bile acids and salts | |||
| PPARA activates gene expression | ||||
| Endogenous sterols | ||||
| WikiPathways | Nuclear Receptors in Lipid Metabolism and Toxicity | |||
| Nuclear Receptors Meta-Pathway | ||||
| Farnesoid X Receptor Pathway | ||||
| Drug Induction of Bile Acid Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. | |||
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