Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0G4YZ
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| Former ID |
DIB005471
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| Drug Name |
11C-PBR-28
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| Synonyms |
Radiolabeled benzodiazepine receptor ligands, NIH; Carbon-11-PBR-101; Carbon-11-PBR-28; Fluorine-18-PBR-06; 11C-PBR-01; 18F-PBR-06
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| Indication | Brain disease [ICD-11: 8C70-8E61; ICD-10: G00-G99] | Phase 2 | [1] | |
| Company |
National Institutes of Health
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| Structure |
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Download2D MOL |
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| Formula |
C21H20N2O3
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| Canonical SMILES |
CC(=O)N(CC1=CC=CC=C1OC)C2=C(C=CN=C2)OC3=CC=CC=C3
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| InChI |
1S/C21H20N2O3/c1-16(24)23(15-17-8-6-7-11-20(17)25-2)19-14-22-13-12-21(19)26-18-9-4-3-5-10-18/h3-14H,15H2,1-2H3/i2-1
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| InChIKey |
DHZBNHMEIOBPAE-JVVVGQRLSA-N
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| CAS Number |
CAS 1005325-43-8
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Translocator protein (TSPO) | Target Info | Binder | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| HTLV-I infection | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT02513589) Molecular Imaging of Inflammation With 18F-PBR06 to Identify Unstable Carotid Plaques in Patients With Stroke. | |||
| REF 2 | PET imaging with [11C]PBR28 can localize and quantify upregulated peripheral benzodiazepine receptors associated with cerebral ischemia in rat. Neurosci Lett. 2007 Jan 16;411(3):200-5. | |||
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