Drug Information
Drug General Information | Top | |||
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Drug ID |
D0G8OD
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Former ID |
DNC005906
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Drug Name |
N-(benzyloxycarbonyl)-leucyl-glycine-nitrile
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Synonyms |
dipeptidyl nitrile, 1; Cbz-Leu-NH-CH2-CN; JMC487688 Compound 8; CHEMBL200161; SCHEMBL6183068; BDBM19768; UFXQLUZNMRVTPU-AWEZNQCLSA-N; 2-[(Z-L-Leu-)Amino]ethanenitrile; benzyl (S)-1-cyanomethylcarbamoyl-3-methylbutylcarbamate; benzyl N-[(1S)-1-[(cyanomethyl)carbamoyl]-3-methylbutyl]carbamate
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C16H21N3O3
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Canonical SMILES |
CC(C)CC(C(=O)NCC#N)NC(=O)OCC1=CC=CC=C1
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InChI |
1S/C16H21N3O3/c1-12(2)10-14(15(20)18-9-8-17)19-16(21)22-11-13-6-4-3-5-7-13/h3-7,12,14H,9-11H2,1-2H3,(H,18,20)(H,19,21)/t14-/m0/s1
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InChIKey |
UFXQLUZNMRVTPU-AWEZNQCLSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Cathepsin K (CTSK) | Target Info | Inhibitor | [1] |
Cathepsin L (CTSL) | Target Info | Inhibitor | [1] | |
Cathepsin S (CTSS) | Target Info | Inhibitor | [1] | |
KEGG Pathway | Lysosome | |||
Phagosome | ||||
Antigen processing and presentation | ||||
Proteoglycans in cancer | ||||
Rheumatoid arthritis | ||||
Tuberculosis | ||||
Osteoclast differentiation | ||||
Toll-like receptor signaling pathway | ||||
NetPath Pathway | IL4 Signaling Pathway | |||
TGF_beta_Receptor Signaling Pathway | ||||
Leptin Signaling Pathway | ||||
IL2 Signaling Pathway | ||||
RANKL Signaling Pathway | ||||
Reactome | Endosomal/Vacuolar pathway | |||
Collagen degradation | ||||
Degradation of the extracellular matrix | ||||
Trafficking and processing of endosomal TLR | ||||
Assembly of collagen fibrils and other multimeric structures | ||||
MHC class II antigen presentation | ||||
Activation of Matrix Metalloproteinases | ||||
WikiPathways | Primary Focal Segmental Glomerulosclerosis FSGS | |||
Class I MHC mediated antigen processing & presentation | ||||
Trafficking and processing of endosomal TLR | ||||
RANKL/RANK Signaling Pathway | ||||
Osteoclast Signaling |
References | Top | |||
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REF 1 | Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. |
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