Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0H2QO
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| Former ID |
DAP001308
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| Drug Name |
Tetrahydrofolic acid
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| Synonyms |
Tetrahydrafolate; Tetrahydrofolate; Tetrahydropteroylglutamate; Tetrahydropteroylglutamic acid; BIT3012; FH4; H4PteGlu; Folate-H4; Th-folate; Tetra-H-folate; Tetrahydropteroyl mono-L-glutamate; N-(5,6,7,8-tetrahydropteroyl)-L-glutamic acid; N-(4-(((2-Amino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)glutamic acid; N-[4-{[(2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}benzoyl]-L-glutamic acid; N-(4-(((2-Amino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid; N-[4-({[(6S)-2-AMINO-4-OXO-1,4,5,6,7,8-HEXAHYDROPTERIDIN-6-YL]METHYL}AMINO)BENZOYL]-L-GLUTAMIC ACID; N-[4-({[(6S)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid; (2S)-2-[[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid; (2S)-2-[[4-[[(6S)-2-amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl]methylamino]benzoyl]amino]pentanedioic acid; (6S)-5,6,7,8-tetrahydropteroylglutamate; (6S)-H4folate; (6S)-THFA; (6S)-Tetrahydrofolic acid; (6S)-tetrahydrofolate; 2-[[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid; 5,6,7,8-Tetrahydropteroyl-L-glutamic acid; 5,6,7,8-tetrahydrofolate; 5,6,7,8-tetrahydrofolic acid
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| Drug Type |
Small molecular drug
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| Indication | Malnutrition [ICD-11: 5B50-5B71] | Approved | [1], [2] | |
| Therapeutic Class |
Dietary supplement
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| Structure |
 |
Download2D MOL |
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| Formula |
C19H23N7O6
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| Canonical SMILES |
C1C(NC2=C(N1)N=C(NC2=O)N)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
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| InChI |
1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t11?,12-/m0/s1
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| InChIKey |
MSTNYGQPCMXVAQ-KIYNQFGBSA-N
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| CAS Number |
CAS 135-16-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3401, 841551, 8146989, 10224798, 14783879, 14857355, 16089619, 16455256, 24900106, 44422393, 46504756, 49972816, 50100135, 53790489, 57334857, 75885299, 84944006, 88727165, 103933386, 104404800, 128642544, 134338525, 135048256, 137239451, 139870152, 140567894, 144236776, 160645899, 160699480, 160963466, 162227310, 164164124, 164765388, 178101389, 215774298, 223737593, 226461237, 250133197, 252554140
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| ChEBI ID |
CHEBI:20506
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Folate receptor (FOLR) | Target Info | Binder | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4675). | |||
| REF 2 | Trimethoprim-sulfamethoxazole in the United States. Ann Intern Med. 1979 Sep;91(3):420-9. | |||
| REF 3 | Common mutations at the homocysteine metabolism pathway and pediatric stroke. Thromb Res. 2001 Apr 15;102(2):115-20. | |||
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