Target Information
| Target General Information | Top | |||||
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| Target ID |
T87467
(Former ID: TTDS00489)
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| Target Name |
Folate receptor (FOLR)
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| Synonyms |
FR; FOLR
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| Gene Name |
NO-GeName
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| Target Type |
Successful target
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[1] | ||||
| Disease | [+] 2 Target-related Diseases | + | ||||
| 1 | Folate deficiency anaemia [ICD-11: 3A02] | |||||
| 2 | Nutritional deficiency [ICD-11: 5B50-5B71] | |||||
| Function |
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform short does not bind folate.
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| BioChemical Class |
Folate receptor
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| UniProt ID | ||||||
| Drugs and Modes of Action | Top | |||||
|---|---|---|---|---|---|---|
| Approved Drug(s) | [+] 2 Approved Drugs | + | ||||
| 1 | Folic Acid | Drug Info | Approved | Vitamin deficiency | [2], [3], [4] | |
| 2 | Tetrahydrofolic acid | Drug Info | Approved | Malnutrition | [5], [6] | |
| Mode of Action | [+] 1 Modes of Action | + | ||||
| Binder | [+] 2 Binder drugs | + | ||||
| 1 | Folic Acid | Drug Info | [7] | |||
| 2 | Tetrahydrofolic acid | Drug Info | [1] | |||
| References | Top | |||||
|---|---|---|---|---|---|---|
| REF 1 | Common mutations at the homocysteine metabolism pathway and pediatric stroke. Thromb Res. 2001 Apr 15;102(2):115-20. | |||||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4563). | |||||
| REF 3 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 040514. | |||||
| REF 4 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||||
| REF 5 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4675). | |||||
| REF 6 | Trimethoprim-sulfamethoxazole in the United States. Ann Intern Med. 1979 Sep;91(3):420-9. | |||||
| REF 7 | Gamma-glutamyl hydrolase and drug resistance. Clin Chim Acta. 2006 Dec;374(1-2):25-32. | |||||
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