Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Z0DW
|
|||
| Former ID |
DAP001309
|
|||
| Drug Name |
Folic Acid
|
|||
| Synonyms |
folic acid; 59-30-3; Folate; Pteroylglutamic acid; Vitamin M; Folacin; Folacid; PteGlu; Vitamin B9; Folvite; Pteroyl-L-glutamic acid; Vitamin Bc; Acifolic; Cytofol; Incafolic; Foliamin; Folsaure; Folicet; Millafol; Folipac; Folettes; Folsan; Folbal; Folsav; Vitamin Be; Pteroyl-L-monoglutamic acid; Mittafol; Folan; Facid; Pteroylmonoglutamic acid; Antianemia factor; Factor U; Folico (Italy); Folina (Italy); Foldine [France]; Pteroylmonoglutamate; Acfol (Spain); Foldine; Folcysteine; Folasic (Australia); Folcidin; Folaemin [Netherlands]; Nifolin; [3H]folic acid
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Folate-deficiency anemia [ICD-11: 3A02.Y; ICD-10: D53] | Approved | [1] | |
| Vitamin deficiency [ICD-11: 5B55-5B71; ICD-10: E56.9] | Approved | [2], [3], [4] | ||
| Therapeutic Class |
Vitamins
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C19H19N7O6
|
|||
| Canonical SMILES |
C1=CC(=CC=C1C(=O)NC(CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=O)NC(=N3)N
|
|||
| InChI |
1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
|
|||
| InChIKey |
OVBPIULPVIDEAO-LBPRGKRZSA-N
|
|||
| CAS Number |
CAS 59-30-3
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
3787, 584223, 829573, 831381, 831592, 831633, 831664, 834516, 835597, 835744, 837196, 841329, 7847138, 7887399, 7887539, 7979297, 8144505, 8149795, 8153763, 10318222, 10321330, 11112150, 11335669, 11360908, 11364275, 11366837, 11369399, 11371658, 11375360, 11377561, 11461880, 11485093, 11489275, 11490565, 11493565, 11495195, 11537760, 14857129, 14930521, 16028504, 16077361, 22389272, 24845192, 24894950, 24894973, 24894977, 24894979, 26612259, 26680757, 26704619
|
|||
| ChEBI ID |
CHEBI:27470
|
|||
| ADReCS Drug ID | BADD_D00952 | |||
| SuperDrug ATC ID |
B03BB01
|
|||
| SuperDrug CAS ID |
cas=000059303
|
|||
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
|
Studied Microbe: Erysipelatoclostridium ramosum
Show/Hide Hierarchy
|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Erysipelatoclostridium ramosum was decreased by Folic acid (adjusted p-values: 1.73E-04). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
|
Studied Microbe: Eubacterium rectale
Show/Hide Hierarchy
|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium rectale was decreased by Folic acid (adjusted p-values: 1.15E-03). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Folate receptor (FOLR) | Target Info | Binder | [6] |
| Proton-coupled folate transporter (SLC46A1) | Target Info | Modulator | [7] | |
| Solute carrier family 19 member 1 (SLC19A1) | Target Info | Modulator | [8] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4563). | |||
| REF 3 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 040514. | |||
| REF 4 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 5 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 6 | Gamma-glutamyl hydrolase and drug resistance. Clin Chim Acta. 2006 Dec;374(1-2):25-32. | |||
| REF 7 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1213). | |||
| REF 8 | Increased activity of a novel low pH folate transporter associated with lipophilic antifolate resistance in chinese hamster ovary cells. J Biol Chem. 1998 Apr 3;273(14):8106-11. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.