| Target and Pathway |
Top |
| Target(s) |
Cyclin-dependent kinase 1 (CDK1) |
Target Info
|
Inhibitor |
[1] |
| Cyclin-dependent kinase 2 (CDK2) |
Target Info
|
Inhibitor |
[1] |
| Cyclin-dependent kinase 4 (CDK4) |
Target Info
|
Inhibitor |
[1] |
| Stress-activated protein kinase 2a (p38 alpha) |
Target Info
|
Inhibitor |
[1] |
| Stress-activated protein kinase JNK1 (JNK1) |
Target Info
|
Inhibitor |
[1] |
| Stress-activated protein kinase JNK2 (JNK2) |
Target Info
|
Inhibitor |
[1] |
| Stress-activated protein kinase JNK3 (JNK3) |
Target Info
|
Inhibitor |
[1] |
| Target's Patent Info |
Cyclin-dependent kinase 1 (CDK1) |
Target's Patent Info
|
[1] |
| Cyclin-dependent kinase 2 (CDK2) |
Target's Patent Info
|
[1] |
| Cyclin-dependent kinase 4 (CDK4) |
Target's Patent Info
|
[1] |
| Stress-activated protein kinase 2a (p38 alpha) |
Target's Patent Info
|
[1] |
| Stress-activated protein kinase JNK1 (JNK1) |
Target's Patent Info
|
[1] |
| Stress-activated protein kinase JNK2 (JNK2) |
Target's Patent Info
|
[1] |
| Stress-activated protein kinase JNK3 (JNK3) |
Target's Patent Info
|
[1] |
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KEGG Pathway
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Cell cycle
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Oocyte meiosis
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p53 signaling pathway
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Gap junction
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Progesterone-mediated oocyte maturation
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Herpes simplex infection
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Epstein-Barr virus infection
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Viral carcinogenesis
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PI3K-Akt signaling pathway
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Tight junction
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T cell receptor signaling pathway
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Hepatitis B
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Measles
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HTLV-I infection
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Pathways in cancer
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Pancreatic cancer
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Glioma
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Melanoma
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Bladder cancer
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Chronic myeloid leukemia
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Small cell lung cancer
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Non-small cell lung cancer
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FoxO signaling pathway
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Prostate cancer
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MAPK signaling pathway
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ErbB signaling pathway
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Ras signaling pathway
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cAMP signaling pathway
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Sphingolipid signaling pathway
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Protein processing in endoplasmic reticulum
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Wnt signaling pathway
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Osteoclast differentiation
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Focal adhesion
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Toll-like receptor signaling pathway
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NOD-like receptor signaling pathway
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RIG-I-like receptor signaling pathway
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Fc epsilon RI signaling pathway
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TNF signaling pathway
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Neurotrophin signaling pathway
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Retrograde endocannabinoid signaling
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Dopaminergic synapse
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Inflammatory mediator regulation of TRP channels
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Insulin signaling pathway
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GnRH signaling pathway
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Prolactin signaling pathway
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Adipocytokine signaling pathway
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Type II diabetes mellitus
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Non-alcoholic fatty liver disease (NAFLD)
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Epithelial cell signaling in Helicobacter pylori infection
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Shigellosis
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Salmonella infection
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Pertussis
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Chagas disease (American trypanosomiasis)
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Toxoplasmosis
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Tuberculosis
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Hepatitis C
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Influenza A
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Colorectal cancer
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Choline metabolism in cancer
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Rap1 signaling pathway
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Adrenergic signaling in cardiomyocytes
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VEGF signaling pathway
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Signaling pathways regulating pluripotency of stem cells
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Platelet activation
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Leukocyte transendothelial migration
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Amyotrophic lateral sclerosis (ALS)
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Leishmaniasis
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Proteoglycans in cancer
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NetPath Pathway
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RANKL Signaling Pathway
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TCR Signaling Pathway
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EGFR1 Signaling Pathway
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IL5 Signaling Pathway
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TNFalpha Signaling Pathway
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FSH Signaling Pathway
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Panther Pathway
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p53 pathway
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p53 pathway feedback loops 2
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Alzheimer disease-amyloid secretase pathway
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Apoptosis signaling pathway
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B cell activation
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EGF receptor signaling pathway
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FAS signaling pathway
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FGF signaling pathway
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Integrin signalling pathway
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Interferon-gamma signaling pathway
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Parkinson disease
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TGF-beta signaling pathway
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Ras Pathway
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CCKR signaling map ST
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Huntington disease
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Oxidative stress response
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T cell activation
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Toll receptor signaling pathway
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Angiogenesis
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PDGF signaling pathway
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VEGF signaling pathway
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p38 MAPK pathway
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Pathwhiz Pathway
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Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
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Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
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Fc Epsilon Receptor I Signaling in Mast Cells
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Pathway Interaction Database
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p73 transcription factor network
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E2F transcription factor network
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PLK1 signaling events
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AP-1 transcription factor network
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FOXM1 transcription factor network
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Retinoic acid receptors-mediated signaling
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Regulation of nuclear SMAD2/3 signaling
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Calcineurin-regulated NFAT-dependent transcription in lymphocytes
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Validated targets of C-MYC transcriptional activation
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ATF-2 transcription factor network
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Regulation of retinoblastoma protein
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Signaling events mediated by PRL
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ATR signaling pathway
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mTOR signaling pathway
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IL2-mediated signaling events
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FoxO family signaling
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BARD1 signaling events
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p53 pathway
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Noncanonical Wnt signaling pathway
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CD40/CD40L signaling
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FAS (CD95) signaling pathway
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Glucocorticoid receptor regulatory network
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p75(NTR)-mediated signaling
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ErbB2/ErbB3 signaling events
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PDGFR-beta signaling pathway
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Nephrin/Neph1 signaling in the kidney podocyte
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CDC42 signaling events
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Role of Calcineurin-dependent NFAT signaling in lymphocytes
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Rapid glucocorticoid signaling
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ErbB1 downstream signaling
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Downstream signaling in naï
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RAC1 signaling pathway
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Signaling events mediated by focal adhesion kinase
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Glypican 3 network
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IL12 signaling mediated by STAT4
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Fc-epsilon receptor I signaling in mast cells
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Endothelins
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BCR signaling pathway
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RhoA signaling pathway
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Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
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Osteopontin-mediated events
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Reelin signaling pathway
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TRAIL signaling pathway
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Signaling events regulated by Ret tyrosine kinase
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Angiopoietin receptor Tie2-mediated signaling
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IL1-mediated signaling events
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Ceramide signaling pathway
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Regulation of Androgen receptor activity
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JNK signaling in the CD4+ TCR pathway
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HIV-1 Nef: Negative effector of Fas and TNF-alpha
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Signaling events mediated by Stem cell factor receptor (c-Kit)
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EPO signaling pathway
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Syndecan-2-mediated signaling events
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Ephrin B reverse signaling
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N-cadherin signaling events
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S1P2 pathway
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p38 MAPK signaling pathway
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Atypical NF-kappaB pathway
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IL4-mediated signaling events
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IL12-mediated signaling events
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Regulation of p38-alpha and p38-beta
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Thromboxane A2 receptor signaling
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IL6-mediated signaling events
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p38 signaling mediated by MAPKAP kinases
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CXCR3-mediated signaling events
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Signaling mediated by p38-alpha and p38-beta
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Signaling events mediated by VEGFR1 and VEGFR2
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Trk receptor signaling mediated by the MAPK pathway
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VEGFR3 signaling in lymphatic endothelium
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FGF signaling pathway
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Reactome
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MAPK3 (ERK1) activation
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E2F mediated regulation of DNA replication
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G0 and Early G1
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Cyclin B2 mediated events
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Golgi Cisternae Pericentriolar Stack Reorganization
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Cdc20:Phospho-APC/C mediated degradation of Cyclin A
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Regulation of APC/C activators between G1/S and early anaphase
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Phosphorylation of the APC/C
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Phosphorylation of Emi1
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Condensation of Prophase Chromosomes
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MASTL Facilitates Mitotic Progression
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Resolution of Sister Chromatid Cohesion
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Condensation of Prometaphase Chromosomes
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Regulation of PLK1 Activity at G2/M Transition
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Activation of NIMA Kinases NEK9, NEK6, NEK7
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Loss of Nlp from mitotic centrosomes
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Recruitment of mitotic centrosome proteins and complexes
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Loss of proteins required for interphase microtubule organization?from the centrosome
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Recruitment of NuMA to mitotic centrosomes
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Depolymerisation of the Nuclear Lamina
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Anchoring of the basal body to the plasma membrane
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MAPK6/MAPK4 signaling
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G1/S-Specific Transcription
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Cyclin A/B1 associated events during G2/M transition
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G2/M DNA replication checkpoint
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Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
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Oxidative Stress Induced Senescence
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Senescence-Associated Secretory Phenotype (SASP)
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Oncogene Induced Senescence
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RMTs methylate histone arginines
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Transcriptional regulation of white adipocyte differentiation
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Ubiquitin-dependent degradation of Cyclin D1
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Cyclin D associated events in G1
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Meiotic recombination
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Activation of ATR in response to replication stress
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SCF(Skp2)-mediated degradation of p27/p21
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DNA Damage/Telomere Stress Induced Senescence
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Processing of DNA double-strand break ends
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G2 Phase
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Orc1 removal from chromatin
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Cyclin E associated events during G1/S transition
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p53-Dependent G1 DNA Damage Response
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Cyclin A:Cdk2-associated events at S phase entry
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Factors involved in megakaryocyte development and platelet production
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FCERI mediated MAPK activation
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JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
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Activation of the AP-1 family of transcription factors
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NRAGE signals death through JNK
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NRIF signals cell death from the nucleus
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DSCAM interactions
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Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
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NOD1/2 Signaling Pathway
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p38MAPK events
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ERK/MAPK targets
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Activation of PPARGC1A (PGC-1alpha) by phosphorylation
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CDO in myogenesis
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ADP signalling through P2Y purinoceptor 1
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Platelet sensitization by LDL
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VEGFA-VEGFR2 Pathway
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activated TAK1 mediates p38 MAPK activation
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KSRP (KHSRP) binds and destabilizes mRNA
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WikiPathways
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DNA Damage Response
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G1 to S cell cycle control
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TGF beta Signaling Pathway
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PPAR Alpha Pathway
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MAP kinase activation in TLR cascade
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RAF/MAP kinase cascade
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Mitotic Prophase
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Mitotic Prometaphase
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BMI1
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ATM Signaling Pathway
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Retinoblastoma (RB) in Cancer
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Spinal Cord Injury
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Prostate Cancer
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Regulation of Microtubule Cytoskeleton
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Integrated Cancer pathway
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Mitotic G2-G2/M phases
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Mitotic G1-G1/S phases
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Cell Cycle
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APC/C-mediated degradation of cell cycle proteins
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Cell Cycle Checkpoints
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miRNA Regulation of DNA Damage Response
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Ovarian Infertility Genes
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Bladder Cancer
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S Phase
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Transcriptional Regulation of White Adipocyte Differentiation
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Meiotic Recombination
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Integrated Pancreatic Cancer Pathway
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Signaling Pathways in Glioblastoma
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TSH signaling pathway
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Integrated Breast Cancer Pathway
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ID signaling pathway
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DNA Replication
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M/G1 Transition
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Aryl Hydrocarbon Receptor
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Oncostatin M Signaling Pathway
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Synthesis of DNA
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Regulation of DNA replication
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Factors involved in megakaryocyte development and platelet production
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Toll-like receptor signaling pathway
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DNA Damage Response (only ATM dependent)
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G13 Signaling Pathway
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Insulin Signaling
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Wnt Signaling Pathway
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MAPK Cascade
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Oxidative Stress
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Wnt Signaling Pathway and Pluripotency
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Apoptosis Modulation by HSP70
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MAPK Signaling Pathway
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Nanoparticle-mediated activation of receptor signaling
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Structural Pathway of Interleukin 1 (IL-1)
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Apoptosis
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BDNF signaling pathway
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Integrin-mediated Cell Adhesion
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Regulation of toll-like receptor signaling pathway
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TCR Signaling Pathway
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TGF Beta Signaling Pathway
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EGF/EGFR Signaling Pathway
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JAK/STAT
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Corticotropin-releasing hormone
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AGE/RAGE pathway
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TNF alpha Signaling Pathway
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B Cell Receptor Signaling Pathway
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TSLP Signaling Pathway
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TWEAK Signaling Pathway
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RANKL/RANK Signaling Pathway
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IL-1 signaling pathway
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ErbB Signaling Pathway
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FAS pathway and Stress induction of HSP regulation
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Signaling of Hepatocyte Growth Factor Receptor
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Kit receptor signaling pathway
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Transcriptional activation by NRF2
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NLR Proteins
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IL-3 Signaling Pathway
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Cardiac Hypertrophic Response
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EBV LMP1 signaling
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PDGF Pathway
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Nanoparticle triggered regulated necrosis
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Leptin signaling pathway
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Signalling by NGF
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Intrinsic Pathway for Apoptosis
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DSCAM interactions
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Apoptosis Modulation and Signaling
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Type II diabetes mellitus
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MicroRNAs in cardiomyocyte hypertrophy
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Physiological and Pathological Hypertrophy of the Heart
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Osteoclast Signaling
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Monoamine Transport
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Serotonin HTR1 Group and FOS Pathway
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Senescence and Autophagy in Cancer
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Interferon type I signaling pathways
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p38 MAPK Signaling Pathway
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IL-4 Signaling Pathway
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Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
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Amyotrophic lateral sclerosis (ALS)
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Alpha 6 Beta 4 signaling pathway
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Cardiac Progenitor Differentiation
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Parkinsons Disease Pathway
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FSH signaling pathway
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miR-targeted genes in muscle cell - TarBase
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miR-targeted genes in lymphocytes - TarBase
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miR-targeted genes in leukocytes - TarBase
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miR-targeted genes in epithelium - TarBase
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Signal amplification
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Platelet homeostasis
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NGF signalling via TRKA from the plasma membrane
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Myogenesis
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Angiogenesis
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