Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0H4NK
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| Former ID |
DIB018514
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| Drug Name |
1-phenylbiguanide
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| Synonyms |
phenylbiguanide; 1-Phenylbiguanide; Phenyl biguanide; 102-02-3; Phenyldiguanide; Phenylguanide; phenyl diguanide; N-Phenyl-N'-guanylguanidine; N-phenylimidodicarbonimidic diamide; Biguanide, phenyl-; Imidodicarbonimidic diamide, N-phenyl-; UNII-W8PKA3T2I3; BIGUANIDE, 1-PHENYL-; C8H11N5; N-Phenyl-imidocarbonimidic diamide; EINECS 202-998-5; W8PKA3T2I3; CHEMBL13791; CHEBI:75377; P 1426; Imidodicarbonimidicdiamide, N-phenyl-; 1-(diaminomethylidene)-2-phenylguanidine; SR-01000075565; N-phenylbiguanide; N'-phenylbiguanide
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C8H11N5
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| Canonical SMILES |
C1=CC=C(C=C1)N=C(N)N=C(N)N
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| InChI |
1S/C8H11N5/c9-7(10)13-8(11)12-6-4-2-1-3-5-6/h1-5H,(H6,9,10,11,12,13)
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| InChIKey |
CUQCMXFWIMOWRP-UHFFFAOYSA-N
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| CAS Number |
CAS 102-02-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
625012, 3137083, 3286785, 5292419, 5360933, 8150149, 10502442, 10990284, 11111589, 11113825, 11335457, 11335924, 11360696, 11361163, 11363366, 11364354, 11364771, 11365928, 11366916, 11367333, 11368490, 11369478, 11369895, 11372526, 11372935, 11373694, 11374079, 11375495, 11376652, 11377640, 11378060, 11455248, 11456191, 11461668, 11462135, 11484975, 11489006, 11491419, 11491873, 11492135, 11494286, 11495274, 15147255, 17405545, 24263014, 24850064, 26751999, 29223864, 47291033, 47291034
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| ChEBI ID |
CHEBI:75377
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 3A receptor (HTR3A) | Target Info | Agonist | [2] |
| 5-HT 3B receptor (HTR3B) | Target Info | Agonist | [3] | |
| KEGG Pathway | Serotonergic synapse | |||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Panther Pathway | 5HT3 type receptor mediated signaling pathway | |||
| Reactome | Ligand-gated ion channel transport | |||
| WikiPathways | Iron uptake and transport | |||
| SIDS Susceptibility Pathways | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2284). | |||
| REF 2 | Allosteric interactions among agonists and antagonists at 5-hydroxytryptamine3 receptors. J Neurochem. 1995 Jul;65(1):104-10. | |||
| REF 3 | Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors. Neuropharmacology. 2001 Aug;41(2):282-4. | |||
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